Cargando…

Preventive Effects of Fermented Brown Rice and Rice Bran against Prostate Carcinogenesis in TRAP Rats

Fermented brown rice and rice bran with Aspergillus oryzae (FBRA) is considered to have the potential to prevent chemically-induced carcinogenesis in multiple organs of rodents. In the present study, we evaluated the possible chemopreventive effects of FBRA against prostate tumorigenesis. Six-week-o...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuno, Toshiya, Nagano, Aya, Mori, Yukiko, Kato, Hiroyuki, Nagayasu, Yuko, Naiki-Ito, Aya, Suzuki, Shugo, Mori, Hideki, Takahashi, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963897/
https://www.ncbi.nlm.nih.gov/pubmed/27409632
http://dx.doi.org/10.3390/nu8070421
_version_ 1782445002598645760
author Kuno, Toshiya
Nagano, Aya
Mori, Yukiko
Kato, Hiroyuki
Nagayasu, Yuko
Naiki-Ito, Aya
Suzuki, Shugo
Mori, Hideki
Takahashi, Satoru
author_facet Kuno, Toshiya
Nagano, Aya
Mori, Yukiko
Kato, Hiroyuki
Nagayasu, Yuko
Naiki-Ito, Aya
Suzuki, Shugo
Mori, Hideki
Takahashi, Satoru
author_sort Kuno, Toshiya
collection PubMed
description Fermented brown rice and rice bran with Aspergillus oryzae (FBRA) is considered to have the potential to prevent chemically-induced carcinogenesis in multiple organs of rodents. In the present study, we evaluated the possible chemopreventive effects of FBRA against prostate tumorigenesis. Six-week-old male rats of the transgenic rat for adenocarcinoma of prostate (TRAP) strain were fed diets containing 5% or 10% FBRA for 15 weeks. Animals were sacrificed at 21 weeks of age, and the ventral and lateral prostate were removed for histopathological evaluation and immunoblot analyses. FBRA decreased the incidence of adenocarcinoma in the lateral prostate and suppressed the progression of prostate carcinogenesis. Treatment with FBRA induced apoptosis and inhibited cell proliferation in histologically high-grade prostatic intraepithelial neoplasias. Phospho-AMP-activated kinase α (Thr172) was up-regulated in the prostate of rats fed the diet supplemented with FBRA. These results indicate that FBRA controls tumor growth by activating pathways responsive to energy deprivation and suggest that FBRA has translational potential for the prevention of human prostate cancer.
format Online
Article
Text
id pubmed-4963897
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-49638972016-08-03 Preventive Effects of Fermented Brown Rice and Rice Bran against Prostate Carcinogenesis in TRAP Rats Kuno, Toshiya Nagano, Aya Mori, Yukiko Kato, Hiroyuki Nagayasu, Yuko Naiki-Ito, Aya Suzuki, Shugo Mori, Hideki Takahashi, Satoru Nutrients Article Fermented brown rice and rice bran with Aspergillus oryzae (FBRA) is considered to have the potential to prevent chemically-induced carcinogenesis in multiple organs of rodents. In the present study, we evaluated the possible chemopreventive effects of FBRA against prostate tumorigenesis. Six-week-old male rats of the transgenic rat for adenocarcinoma of prostate (TRAP) strain were fed diets containing 5% or 10% FBRA for 15 weeks. Animals were sacrificed at 21 weeks of age, and the ventral and lateral prostate were removed for histopathological evaluation and immunoblot analyses. FBRA decreased the incidence of adenocarcinoma in the lateral prostate and suppressed the progression of prostate carcinogenesis. Treatment with FBRA induced apoptosis and inhibited cell proliferation in histologically high-grade prostatic intraepithelial neoplasias. Phospho-AMP-activated kinase α (Thr172) was up-regulated in the prostate of rats fed the diet supplemented with FBRA. These results indicate that FBRA controls tumor growth by activating pathways responsive to energy deprivation and suggest that FBRA has translational potential for the prevention of human prostate cancer. MDPI 2016-07-11 /pmc/articles/PMC4963897/ /pubmed/27409632 http://dx.doi.org/10.3390/nu8070421 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kuno, Toshiya
Nagano, Aya
Mori, Yukiko
Kato, Hiroyuki
Nagayasu, Yuko
Naiki-Ito, Aya
Suzuki, Shugo
Mori, Hideki
Takahashi, Satoru
Preventive Effects of Fermented Brown Rice and Rice Bran against Prostate Carcinogenesis in TRAP Rats
title Preventive Effects of Fermented Brown Rice and Rice Bran against Prostate Carcinogenesis in TRAP Rats
title_full Preventive Effects of Fermented Brown Rice and Rice Bran against Prostate Carcinogenesis in TRAP Rats
title_fullStr Preventive Effects of Fermented Brown Rice and Rice Bran against Prostate Carcinogenesis in TRAP Rats
title_full_unstemmed Preventive Effects of Fermented Brown Rice and Rice Bran against Prostate Carcinogenesis in TRAP Rats
title_short Preventive Effects of Fermented Brown Rice and Rice Bran against Prostate Carcinogenesis in TRAP Rats
title_sort preventive effects of fermented brown rice and rice bran against prostate carcinogenesis in trap rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963897/
https://www.ncbi.nlm.nih.gov/pubmed/27409632
http://dx.doi.org/10.3390/nu8070421
work_keys_str_mv AT kunotoshiya preventiveeffectsoffermentedbrownriceandricebranagainstprostatecarcinogenesisintraprats
AT naganoaya preventiveeffectsoffermentedbrownriceandricebranagainstprostatecarcinogenesisintraprats
AT moriyukiko preventiveeffectsoffermentedbrownriceandricebranagainstprostatecarcinogenesisintraprats
AT katohiroyuki preventiveeffectsoffermentedbrownriceandricebranagainstprostatecarcinogenesisintraprats
AT nagayasuyuko preventiveeffectsoffermentedbrownriceandricebranagainstprostatecarcinogenesisintraprats
AT naikiitoaya preventiveeffectsoffermentedbrownriceandricebranagainstprostatecarcinogenesisintraprats
AT suzukishugo preventiveeffectsoffermentedbrownriceandricebranagainstprostatecarcinogenesisintraprats
AT morihideki preventiveeffectsoffermentedbrownriceandricebranagainstprostatecarcinogenesisintraprats
AT takahashisatoru preventiveeffectsoffermentedbrownriceandricebranagainstprostatecarcinogenesisintraprats