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Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet
Experience suggests that many celiac patients suffer from persistent symptoms despite a long-term gluten-free diet (GFD). We investigated the prevalence and severity of these symptoms in patients with variable duration of GFD. Altogether, 856 patients were classified into untreated (n = 128), short-...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963905/ https://www.ncbi.nlm.nih.gov/pubmed/27428994 http://dx.doi.org/10.3390/nu8070429 |
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author | Laurikka, Pilvi Salmi, Teea Collin, Pekka Huhtala, Heini Mäki, Markku Kaukinen, Katri Kurppa, Kalle |
author_facet | Laurikka, Pilvi Salmi, Teea Collin, Pekka Huhtala, Heini Mäki, Markku Kaukinen, Katri Kurppa, Kalle |
author_sort | Laurikka, Pilvi |
collection | PubMed |
description | Experience suggests that many celiac patients suffer from persistent symptoms despite a long-term gluten-free diet (GFD). We investigated the prevalence and severity of these symptoms in patients with variable duration of GFD. Altogether, 856 patients were classified into untreated (n = 128), short-term GFD (1–2 years, n = 93) and long-term GFD (≥3 years, n = 635) groups. Analyses were made of clinical and histological data and dietary adherence. Symptoms were evaluated by the validated GSRS questionnaire. One-hundred-sixty healthy subjects comprised the control group. Further, the severity of symptoms was compared with that in peptic ulcer, reflux disease, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Altogether, 93% of the short-term and 94% of the long-term treated patients had a strict GFD and recovered mucosa. Untreated patients had more diarrhea, indigestion and abdominal pain than those on GFD and controls. There were no differences in symptoms between the short- and long-term GFD groups, but both yielded poorer GSRS total score than controls (p = 0.03 and p = 0.05, respectively). Furthermore, patients treated 1–2 years had more diarrhea (p = 0.03) and those treated >10 years more reflux (p = 0.04) than controls. Long-term treated celiac patients showed relatively mild symptoms compared with other gastrointestinal diseases. Based on our results, good response to GFD sustained in long-term follow-up, but not all patients reach the level of healthy individuals. |
format | Online Article Text |
id | pubmed-4963905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49639052016-08-03 Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet Laurikka, Pilvi Salmi, Teea Collin, Pekka Huhtala, Heini Mäki, Markku Kaukinen, Katri Kurppa, Kalle Nutrients Article Experience suggests that many celiac patients suffer from persistent symptoms despite a long-term gluten-free diet (GFD). We investigated the prevalence and severity of these symptoms in patients with variable duration of GFD. Altogether, 856 patients were classified into untreated (n = 128), short-term GFD (1–2 years, n = 93) and long-term GFD (≥3 years, n = 635) groups. Analyses were made of clinical and histological data and dietary adherence. Symptoms were evaluated by the validated GSRS questionnaire. One-hundred-sixty healthy subjects comprised the control group. Further, the severity of symptoms was compared with that in peptic ulcer, reflux disease, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Altogether, 93% of the short-term and 94% of the long-term treated patients had a strict GFD and recovered mucosa. Untreated patients had more diarrhea, indigestion and abdominal pain than those on GFD and controls. There were no differences in symptoms between the short- and long-term GFD groups, but both yielded poorer GSRS total score than controls (p = 0.03 and p = 0.05, respectively). Furthermore, patients treated 1–2 years had more diarrhea (p = 0.03) and those treated >10 years more reflux (p = 0.04) than controls. Long-term treated celiac patients showed relatively mild symptoms compared with other gastrointestinal diseases. Based on our results, good response to GFD sustained in long-term follow-up, but not all patients reach the level of healthy individuals. MDPI 2016-07-14 /pmc/articles/PMC4963905/ /pubmed/27428994 http://dx.doi.org/10.3390/nu8070429 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Laurikka, Pilvi Salmi, Teea Collin, Pekka Huhtala, Heini Mäki, Markku Kaukinen, Katri Kurppa, Kalle Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet |
title | Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet |
title_full | Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet |
title_fullStr | Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet |
title_full_unstemmed | Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet |
title_short | Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet |
title_sort | gastrointestinal symptoms in celiac disease patients on a long-term gluten-free diet |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963905/ https://www.ncbi.nlm.nih.gov/pubmed/27428994 http://dx.doi.org/10.3390/nu8070429 |
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