Cargando…

Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet

Experience suggests that many celiac patients suffer from persistent symptoms despite a long-term gluten-free diet (GFD). We investigated the prevalence and severity of these symptoms in patients with variable duration of GFD. Altogether, 856 patients were classified into untreated (n = 128), short-...

Descripción completa

Detalles Bibliográficos
Autores principales: Laurikka, Pilvi, Salmi, Teea, Collin, Pekka, Huhtala, Heini, Mäki, Markku, Kaukinen, Katri, Kurppa, Kalle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963905/
https://www.ncbi.nlm.nih.gov/pubmed/27428994
http://dx.doi.org/10.3390/nu8070429
_version_ 1782445004439945216
author Laurikka, Pilvi
Salmi, Teea
Collin, Pekka
Huhtala, Heini
Mäki, Markku
Kaukinen, Katri
Kurppa, Kalle
author_facet Laurikka, Pilvi
Salmi, Teea
Collin, Pekka
Huhtala, Heini
Mäki, Markku
Kaukinen, Katri
Kurppa, Kalle
author_sort Laurikka, Pilvi
collection PubMed
description Experience suggests that many celiac patients suffer from persistent symptoms despite a long-term gluten-free diet (GFD). We investigated the prevalence and severity of these symptoms in patients with variable duration of GFD. Altogether, 856 patients were classified into untreated (n = 128), short-term GFD (1–2 years, n = 93) and long-term GFD (≥3 years, n = 635) groups. Analyses were made of clinical and histological data and dietary adherence. Symptoms were evaluated by the validated GSRS questionnaire. One-hundred-sixty healthy subjects comprised the control group. Further, the severity of symptoms was compared with that in peptic ulcer, reflux disease, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Altogether, 93% of the short-term and 94% of the long-term treated patients had a strict GFD and recovered mucosa. Untreated patients had more diarrhea, indigestion and abdominal pain than those on GFD and controls. There were no differences in symptoms between the short- and long-term GFD groups, but both yielded poorer GSRS total score than controls (p = 0.03 and p = 0.05, respectively). Furthermore, patients treated 1–2 years had more diarrhea (p = 0.03) and those treated >10 years more reflux (p = 0.04) than controls. Long-term treated celiac patients showed relatively mild symptoms compared with other gastrointestinal diseases. Based on our results, good response to GFD sustained in long-term follow-up, but not all patients reach the level of healthy individuals.
format Online
Article
Text
id pubmed-4963905
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-49639052016-08-03 Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet Laurikka, Pilvi Salmi, Teea Collin, Pekka Huhtala, Heini Mäki, Markku Kaukinen, Katri Kurppa, Kalle Nutrients Article Experience suggests that many celiac patients suffer from persistent symptoms despite a long-term gluten-free diet (GFD). We investigated the prevalence and severity of these symptoms in patients with variable duration of GFD. Altogether, 856 patients were classified into untreated (n = 128), short-term GFD (1–2 years, n = 93) and long-term GFD (≥3 years, n = 635) groups. Analyses were made of clinical and histological data and dietary adherence. Symptoms were evaluated by the validated GSRS questionnaire. One-hundred-sixty healthy subjects comprised the control group. Further, the severity of symptoms was compared with that in peptic ulcer, reflux disease, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Altogether, 93% of the short-term and 94% of the long-term treated patients had a strict GFD and recovered mucosa. Untreated patients had more diarrhea, indigestion and abdominal pain than those on GFD and controls. There were no differences in symptoms between the short- and long-term GFD groups, but both yielded poorer GSRS total score than controls (p = 0.03 and p = 0.05, respectively). Furthermore, patients treated 1–2 years had more diarrhea (p = 0.03) and those treated >10 years more reflux (p = 0.04) than controls. Long-term treated celiac patients showed relatively mild symptoms compared with other gastrointestinal diseases. Based on our results, good response to GFD sustained in long-term follow-up, but not all patients reach the level of healthy individuals. MDPI 2016-07-14 /pmc/articles/PMC4963905/ /pubmed/27428994 http://dx.doi.org/10.3390/nu8070429 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Laurikka, Pilvi
Salmi, Teea
Collin, Pekka
Huhtala, Heini
Mäki, Markku
Kaukinen, Katri
Kurppa, Kalle
Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet
title Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet
title_full Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet
title_fullStr Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet
title_full_unstemmed Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet
title_short Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet
title_sort gastrointestinal symptoms in celiac disease patients on a long-term gluten-free diet
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963905/
https://www.ncbi.nlm.nih.gov/pubmed/27428994
http://dx.doi.org/10.3390/nu8070429
work_keys_str_mv AT laurikkapilvi gastrointestinalsymptomsinceliacdiseasepatientsonalongtermglutenfreediet
AT salmiteea gastrointestinalsymptomsinceliacdiseasepatientsonalongtermglutenfreediet
AT collinpekka gastrointestinalsymptomsinceliacdiseasepatientsonalongtermglutenfreediet
AT huhtalaheini gastrointestinalsymptomsinceliacdiseasepatientsonalongtermglutenfreediet
AT makimarkku gastrointestinalsymptomsinceliacdiseasepatientsonalongtermglutenfreediet
AT kaukinenkatri gastrointestinalsymptomsinceliacdiseasepatientsonalongtermglutenfreediet
AT kurppakalle gastrointestinalsymptomsinceliacdiseasepatientsonalongtermglutenfreediet