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Skin tissue engineering advances in severe burns: review and therapeutic applications

Current advances in basic stem cell research and tissue engineering augur well for the development of improved cultured skin tissue substitutes: a class of products that is still fraught with limitations for clinical use. Although the ability to grow autologous keratinocytes in-vitro from a small sk...

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Autores principales: Chua, Alvin Wen Choong, Khoo, Yik Cheong, Tan, Bien Keem, Tan, Kok Chai, Foo, Chee Liam, Chong, Si Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963933/
https://www.ncbi.nlm.nih.gov/pubmed/27574673
http://dx.doi.org/10.1186/s41038-016-0027-y
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author Chua, Alvin Wen Choong
Khoo, Yik Cheong
Tan, Bien Keem
Tan, Kok Chai
Foo, Chee Liam
Chong, Si Jack
author_facet Chua, Alvin Wen Choong
Khoo, Yik Cheong
Tan, Bien Keem
Tan, Kok Chai
Foo, Chee Liam
Chong, Si Jack
author_sort Chua, Alvin Wen Choong
collection PubMed
description Current advances in basic stem cell research and tissue engineering augur well for the development of improved cultured skin tissue substitutes: a class of products that is still fraught with limitations for clinical use. Although the ability to grow autologous keratinocytes in-vitro from a small skin biopsy into sheets of stratified epithelium (within 3 to 4 weeks) helped alleviate the problem of insufficient donor site for extensive burn, many burn units still have to grapple with insufficient skin allografts which are used as intermediate wound coverage after burn excision. Alternatives offered by tissue-engineered skin dermal replacements to meet emergency demand have been used fairly successfully. Despite the availability of these commercial products, they all suffer from the same problems of extremely high cost, sub-normal skin microstructure and inconsistent engraftment, especially in full thickness burns. Clinical practice for severe burn treatment has since evolved to incorporate these tissue-engineered skin substitutes, usually as an adjunct to speed up epithelization for wound closure and/or to improve quality of life by improving the functional and cosmetic results long-term. This review seeks to bring the reader through the beginnings of skin tissue engineering, the utilization of some of the key products developed for the treatment of severe burns and the hope of harnessing stem cells to improve on current practice.
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spelling pubmed-49639332016-08-29 Skin tissue engineering advances in severe burns: review and therapeutic applications Chua, Alvin Wen Choong Khoo, Yik Cheong Tan, Bien Keem Tan, Kok Chai Foo, Chee Liam Chong, Si Jack Burns Trauma Review Current advances in basic stem cell research and tissue engineering augur well for the development of improved cultured skin tissue substitutes: a class of products that is still fraught with limitations for clinical use. Although the ability to grow autologous keratinocytes in-vitro from a small skin biopsy into sheets of stratified epithelium (within 3 to 4 weeks) helped alleviate the problem of insufficient donor site for extensive burn, many burn units still have to grapple with insufficient skin allografts which are used as intermediate wound coverage after burn excision. Alternatives offered by tissue-engineered skin dermal replacements to meet emergency demand have been used fairly successfully. Despite the availability of these commercial products, they all suffer from the same problems of extremely high cost, sub-normal skin microstructure and inconsistent engraftment, especially in full thickness burns. Clinical practice for severe burn treatment has since evolved to incorporate these tissue-engineered skin substitutes, usually as an adjunct to speed up epithelization for wound closure and/or to improve quality of life by improving the functional and cosmetic results long-term. This review seeks to bring the reader through the beginnings of skin tissue engineering, the utilization of some of the key products developed for the treatment of severe burns and the hope of harnessing stem cells to improve on current practice. BioMed Central 2016-02-19 /pmc/articles/PMC4963933/ /pubmed/27574673 http://dx.doi.org/10.1186/s41038-016-0027-y Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Chua, Alvin Wen Choong
Khoo, Yik Cheong
Tan, Bien Keem
Tan, Kok Chai
Foo, Chee Liam
Chong, Si Jack
Skin tissue engineering advances in severe burns: review and therapeutic applications
title Skin tissue engineering advances in severe burns: review and therapeutic applications
title_full Skin tissue engineering advances in severe burns: review and therapeutic applications
title_fullStr Skin tissue engineering advances in severe burns: review and therapeutic applications
title_full_unstemmed Skin tissue engineering advances in severe burns: review and therapeutic applications
title_short Skin tissue engineering advances in severe burns: review and therapeutic applications
title_sort skin tissue engineering advances in severe burns: review and therapeutic applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963933/
https://www.ncbi.nlm.nih.gov/pubmed/27574673
http://dx.doi.org/10.1186/s41038-016-0027-y
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