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The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring

Though survival rate following severe thermal injuries has improved, the incidence and treatment of scarring have not improved at the same speed. This review discusses the formation of scars and in particular the formation of hypertrophic scars. Further, though there is as yet no gold standard treat...

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Autores principales: Mehta, M., Branford, O. A., Rolfe, K. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964041/
https://www.ncbi.nlm.nih.gov/pubmed/27574685
http://dx.doi.org/10.1186/s41038-016-0040-1
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author Mehta, M.
Branford, O. A.
Rolfe, K. J.
author_facet Mehta, M.
Branford, O. A.
Rolfe, K. J.
author_sort Mehta, M.
collection PubMed
description Though survival rate following severe thermal injuries has improved, the incidence and treatment of scarring have not improved at the same speed. This review discusses the formation of scars and in particular the formation of hypertrophic scars. Further, though there is as yet no gold standard treatment for the prevention or treatment of scarring, a brief overview is included. A number of natural therapeutics have shown beneficial effects both in vivo and in vitro with the potential of becoming clinical therapeutics in the future. These natural therapeutics include both plant-based products such as resveratrol, quercetin and epigallocatechin gallate as examples and includes the non-plant-based therapeutic honey. The review also includes potential mechanism of action for the therapeutics, any recorded adverse events and current administration of the therapeutics used. This review discusses a number of potential ‘treatments’ that may reduce or even prevent scarring particularly hypertrophic scarring, which is associated with thermal injuries without compromising wound repair.
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spelling pubmed-49640412016-08-29 The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring Mehta, M. Branford, O. A. Rolfe, K. J. Burns Trauma Review Though survival rate following severe thermal injuries has improved, the incidence and treatment of scarring have not improved at the same speed. This review discusses the formation of scars and in particular the formation of hypertrophic scars. Further, though there is as yet no gold standard treatment for the prevention or treatment of scarring, a brief overview is included. A number of natural therapeutics have shown beneficial effects both in vivo and in vitro with the potential of becoming clinical therapeutics in the future. These natural therapeutics include both plant-based products such as resveratrol, quercetin and epigallocatechin gallate as examples and includes the non-plant-based therapeutic honey. The review also includes potential mechanism of action for the therapeutics, any recorded adverse events and current administration of the therapeutics used. This review discusses a number of potential ‘treatments’ that may reduce or even prevent scarring particularly hypertrophic scarring, which is associated with thermal injuries without compromising wound repair. BioMed Central 2016-05-04 /pmc/articles/PMC4964041/ /pubmed/27574685 http://dx.doi.org/10.1186/s41038-016-0040-1 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Mehta, M.
Branford, O. A.
Rolfe, K. J.
The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring
title The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring
title_full The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring
title_fullStr The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring
title_full_unstemmed The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring
title_short The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring
title_sort evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964041/
https://www.ncbi.nlm.nih.gov/pubmed/27574685
http://dx.doi.org/10.1186/s41038-016-0040-1
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