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Neurosyphilis as a great imitator: a case report

BACKGROUND: Neurosyphilis is defined as any involvement of the central nervous system by the bacterium Treponema pallidum. Movement disorders as manifestations of syphilis have been reported quite rarely. CASE PRESENTATION: We report a case of a 42-year-old Russian man living in Estonia with rapidly...

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Autores principales: Sabre, Liis, Braschinsky, Mark, Taba, Pille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964046/
https://www.ncbi.nlm.nih.gov/pubmed/27465246
http://dx.doi.org/10.1186/s13104-016-2176-2
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author Sabre, Liis
Braschinsky, Mark
Taba, Pille
author_facet Sabre, Liis
Braschinsky, Mark
Taba, Pille
author_sort Sabre, Liis
collection PubMed
description BACKGROUND: Neurosyphilis is defined as any involvement of the central nervous system by the bacterium Treponema pallidum. Movement disorders as manifestations of syphilis have been reported quite rarely. CASE PRESENTATION: We report a case of a 42-year-old Russian man living in Estonia with rapidly progressive dementia and movement disorders manifesting as myoclonus, cerebellar ataxia and parkinsonism. The mini mental state examination score was 12/30. After excluding different neurodegenerative causes, further diagnostic testing was consistent with neurosyphilis. Treatment with penicillin was started and 6 months later his mini mental state examination score was 25/30 and he had no myoclonus, parkinsonism or cerebellar dysfunction. CONCLUSION: Since syphilis is easily diagnosed and treatable, it should be considered and tested in patients with cognitive impairment and movement disorders. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13104-016-2176-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-49640462016-07-29 Neurosyphilis as a great imitator: a case report Sabre, Liis Braschinsky, Mark Taba, Pille BMC Res Notes Case Report BACKGROUND: Neurosyphilis is defined as any involvement of the central nervous system by the bacterium Treponema pallidum. Movement disorders as manifestations of syphilis have been reported quite rarely. CASE PRESENTATION: We report a case of a 42-year-old Russian man living in Estonia with rapidly progressive dementia and movement disorders manifesting as myoclonus, cerebellar ataxia and parkinsonism. The mini mental state examination score was 12/30. After excluding different neurodegenerative causes, further diagnostic testing was consistent with neurosyphilis. Treatment with penicillin was started and 6 months later his mini mental state examination score was 25/30 and he had no myoclonus, parkinsonism or cerebellar dysfunction. CONCLUSION: Since syphilis is easily diagnosed and treatable, it should be considered and tested in patients with cognitive impairment and movement disorders. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13104-016-2176-2) contains supplementary material, which is available to authorized users. BioMed Central 2016-07-28 /pmc/articles/PMC4964046/ /pubmed/27465246 http://dx.doi.org/10.1186/s13104-016-2176-2 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Sabre, Liis
Braschinsky, Mark
Taba, Pille
Neurosyphilis as a great imitator: a case report
title Neurosyphilis as a great imitator: a case report
title_full Neurosyphilis as a great imitator: a case report
title_fullStr Neurosyphilis as a great imitator: a case report
title_full_unstemmed Neurosyphilis as a great imitator: a case report
title_short Neurosyphilis as a great imitator: a case report
title_sort neurosyphilis as a great imitator: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964046/
https://www.ncbi.nlm.nih.gov/pubmed/27465246
http://dx.doi.org/10.1186/s13104-016-2176-2
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