SCISSOR—Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol

INTRODUCTION: The approved analgesic and anti-inflammatory drugs ibuprofen and indometacin block the small GTPase RhoA, a key enzyme that impedes axonal sprouting after axonal damage. Inhibition of the Rho pathway in a central nervous system-effective manner requires higher dosages compared with ort...

Descripción completa

Detalles Bibliográficos
Autores principales: Kopp, Marcel A, Liebscher, Thomas, Watzlawick, Ralf, Martus, Peter, Laufer, Stefan, Blex, Christian, Schindler, Ralf, Jungehulsing, Gerhard J, Knüppel, Sven, Kreutzträger, Martin, Ekkernkamp, Axel, Dirnagl, Ulrich, Strittmatter, Stephen M, Niedeggen, Andreas, Schwab, Jan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964175/
https://www.ncbi.nlm.nih.gov/pubmed/27466236
http://dx.doi.org/10.1136/bmjopen-2015-010651

Ejemplares similares

Ejemplares similares