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Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets
Peroxisome proliferator-activated receptors (PPAR) are transcription factors that modulate energy metabolism in liver, adipose tissue and muscle. High fat diets (HFD) can negatively impact PPAR expression or activity, favoring obesity, dyslipidemia, insulin resistance and other conditions. However,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964378/ https://www.ncbi.nlm.nih.gov/pubmed/27367676 http://dx.doi.org/10.3390/ijms17071002 |
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author | Domínguez-Avila, J. Abraham González-Aguilar, Gustavo A. Alvarez-Parrilla, Emilio de la Rosa, Laura A. |
author_facet | Domínguez-Avila, J. Abraham González-Aguilar, Gustavo A. Alvarez-Parrilla, Emilio de la Rosa, Laura A. |
author_sort | Domínguez-Avila, J. Abraham |
collection | PubMed |
description | Peroxisome proliferator-activated receptors (PPAR) are transcription factors that modulate energy metabolism in liver, adipose tissue and muscle. High fat diets (HFD) can negatively impact PPAR expression or activity, favoring obesity, dyslipidemia, insulin resistance and other conditions. However, polyphenols (PP) found in vegetable foodstuffs are capable of positively modulating this pathway. We therefore focused this review on the possible effects that PP can have on PPAR when administered together with HFD. We found that PP from diverse sources, such as coffee, olives, rice, berries and others, are capable of inducing the expression of genes involved in a decrease of adipose mass, liver and serum lipids and lipid biosynthesis in animal and cell models of HFD. Since cells or gut bacteria can transform PP into different metabolites, it is possible that a synergistic or antagonistic effect ultimately occurs. PP molecules from vegetable sources are an interesting option to maintain or return to a state of energy homeostasis, possibly due to an adequate PPAR expression and activity. |
format | Online Article Text |
id | pubmed-4964378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49643782016-08-03 Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets Domínguez-Avila, J. Abraham González-Aguilar, Gustavo A. Alvarez-Parrilla, Emilio de la Rosa, Laura A. Int J Mol Sci Review Peroxisome proliferator-activated receptors (PPAR) are transcription factors that modulate energy metabolism in liver, adipose tissue and muscle. High fat diets (HFD) can negatively impact PPAR expression or activity, favoring obesity, dyslipidemia, insulin resistance and other conditions. However, polyphenols (PP) found in vegetable foodstuffs are capable of positively modulating this pathway. We therefore focused this review on the possible effects that PP can have on PPAR when administered together with HFD. We found that PP from diverse sources, such as coffee, olives, rice, berries and others, are capable of inducing the expression of genes involved in a decrease of adipose mass, liver and serum lipids and lipid biosynthesis in animal and cell models of HFD. Since cells or gut bacteria can transform PP into different metabolites, it is possible that a synergistic or antagonistic effect ultimately occurs. PP molecules from vegetable sources are an interesting option to maintain or return to a state of energy homeostasis, possibly due to an adequate PPAR expression and activity. MDPI 2016-06-29 /pmc/articles/PMC4964378/ /pubmed/27367676 http://dx.doi.org/10.3390/ijms17071002 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Domínguez-Avila, J. Abraham González-Aguilar, Gustavo A. Alvarez-Parrilla, Emilio de la Rosa, Laura A. Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets |
title | Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets |
title_full | Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets |
title_fullStr | Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets |
title_full_unstemmed | Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets |
title_short | Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets |
title_sort | modulation of ppar expression and activity in response to polyphenolic compounds in high fat diets |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964378/ https://www.ncbi.nlm.nih.gov/pubmed/27367676 http://dx.doi.org/10.3390/ijms17071002 |
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