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Usefulness of Aquaporin 1 as a Prognostic Marker in a Prospective Cohort of Malignant Mesotheliomas

(1) Background: Malignant mesothelioma (MM) is an aggressive tumour of the serosal membranes, associated with exposure to asbestos. Survival is generally poor, but prognostication for individual patients is difficult. We recently described Aquaporin 1 (AQP1) as independent prognostic factor in two s...

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Autores principales: Driml, Jack, Pulford, Emily, Moffat, David, Karapetis, Christos, Kao, Steven, Griggs, Kim, Henderson, Douglas Warrington, Klebe, Sonja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964417/
https://www.ncbi.nlm.nih.gov/pubmed/27376267
http://dx.doi.org/10.3390/ijms17071041
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author Driml, Jack
Pulford, Emily
Moffat, David
Karapetis, Christos
Kao, Steven
Griggs, Kim
Henderson, Douglas Warrington
Klebe, Sonja
author_facet Driml, Jack
Pulford, Emily
Moffat, David
Karapetis, Christos
Kao, Steven
Griggs, Kim
Henderson, Douglas Warrington
Klebe, Sonja
author_sort Driml, Jack
collection PubMed
description (1) Background: Malignant mesothelioma (MM) is an aggressive tumour of the serosal membranes, associated with exposure to asbestos. Survival is generally poor, but prognostication for individual patients is difficult. We recently described Aquaporin 1 (AQP1) as independent prognostic factor in two separate retrospective cohorts of MM patients. Here we assess the usefulness of AQP1 prospectively, and determine the inter-observer agreement in assessing AQP1 scores; (2) Methods: A total of 104 consecutive cases of MM were included. Sufficient tissue for immunohistochemistry was available for 100 cases, and these cases were labelled for AQP1. Labelling was assessed by two pathologists. Complete clinical information and follow up was available for 91 cases; (3) Results: Labelling of ≥50% of tumour cells for AQP indicated improved prognosis in a univariate model (median survival 13 versus 8 months, p = 0.008), but the significance was decreased in a multivariate analysis. Scoring for AQP1 was robust, with an inter-observer kappa value of 0.722, indicating substantial agreement between observers; (4) Conclusion: AQP1 is a useful prognostic marker that can be easily incorporated in existing diagnostic immunohistochemical panels and which can be reliably interpreted by different pathologists.
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spelling pubmed-49644172016-08-03 Usefulness of Aquaporin 1 as a Prognostic Marker in a Prospective Cohort of Malignant Mesotheliomas Driml, Jack Pulford, Emily Moffat, David Karapetis, Christos Kao, Steven Griggs, Kim Henderson, Douglas Warrington Klebe, Sonja Int J Mol Sci Communication (1) Background: Malignant mesothelioma (MM) is an aggressive tumour of the serosal membranes, associated with exposure to asbestos. Survival is generally poor, but prognostication for individual patients is difficult. We recently described Aquaporin 1 (AQP1) as independent prognostic factor in two separate retrospective cohorts of MM patients. Here we assess the usefulness of AQP1 prospectively, and determine the inter-observer agreement in assessing AQP1 scores; (2) Methods: A total of 104 consecutive cases of MM were included. Sufficient tissue for immunohistochemistry was available for 100 cases, and these cases were labelled for AQP1. Labelling was assessed by two pathologists. Complete clinical information and follow up was available for 91 cases; (3) Results: Labelling of ≥50% of tumour cells for AQP indicated improved prognosis in a univariate model (median survival 13 versus 8 months, p = 0.008), but the significance was decreased in a multivariate analysis. Scoring for AQP1 was robust, with an inter-observer kappa value of 0.722, indicating substantial agreement between observers; (4) Conclusion: AQP1 is a useful prognostic marker that can be easily incorporated in existing diagnostic immunohistochemical panels and which can be reliably interpreted by different pathologists. MDPI 2016-06-30 /pmc/articles/PMC4964417/ /pubmed/27376267 http://dx.doi.org/10.3390/ijms17071041 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Driml, Jack
Pulford, Emily
Moffat, David
Karapetis, Christos
Kao, Steven
Griggs, Kim
Henderson, Douglas Warrington
Klebe, Sonja
Usefulness of Aquaporin 1 as a Prognostic Marker in a Prospective Cohort of Malignant Mesotheliomas
title Usefulness of Aquaporin 1 as a Prognostic Marker in a Prospective Cohort of Malignant Mesotheliomas
title_full Usefulness of Aquaporin 1 as a Prognostic Marker in a Prospective Cohort of Malignant Mesotheliomas
title_fullStr Usefulness of Aquaporin 1 as a Prognostic Marker in a Prospective Cohort of Malignant Mesotheliomas
title_full_unstemmed Usefulness of Aquaporin 1 as a Prognostic Marker in a Prospective Cohort of Malignant Mesotheliomas
title_short Usefulness of Aquaporin 1 as a Prognostic Marker in a Prospective Cohort of Malignant Mesotheliomas
title_sort usefulness of aquaporin 1 as a prognostic marker in a prospective cohort of malignant mesotheliomas
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964417/
https://www.ncbi.nlm.nih.gov/pubmed/27376267
http://dx.doi.org/10.3390/ijms17071041
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