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Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System

Intra-articular injection of platelet-rich plasma (PRP) has been established as a suitable treatment for knee osteoarthritis. Here, we present a double-blind randomized controlled clinical trial, conducted in a public Hospital of the Spanish National Health Care System, to evaluate the efficacy of i...

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Autores principales: Montañez-Heredia, Elvira, Irízar, Sofia, Huertas, Pedro J., Otero, Esperanza, del Valle, Marta, Prat, Isidro, Díaz-Gallardo, Macarena S., Perán, Macarena, Marchal, Juan A., Hernandez-Lamas, María del Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964440/
https://www.ncbi.nlm.nih.gov/pubmed/27384560
http://dx.doi.org/10.3390/ijms17071064
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author Montañez-Heredia, Elvira
Irízar, Sofia
Huertas, Pedro J.
Otero, Esperanza
del Valle, Marta
Prat, Isidro
Díaz-Gallardo, Macarena S.
Perán, Macarena
Marchal, Juan A.
Hernandez-Lamas, María del Carmen
author_facet Montañez-Heredia, Elvira
Irízar, Sofia
Huertas, Pedro J.
Otero, Esperanza
del Valle, Marta
Prat, Isidro
Díaz-Gallardo, Macarena S.
Perán, Macarena
Marchal, Juan A.
Hernandez-Lamas, María del Carmen
author_sort Montañez-Heredia, Elvira
collection PubMed
description Intra-articular injection of platelet-rich plasma (PRP) has been established as a suitable treatment for knee osteoarthritis. Here, we present a double-blind randomized controlled clinical trial, conducted in a public Hospital of the Spanish National Health Care System, to evaluate the efficacy of injecting autologous PRP versus hyaluronic acid (HA) in knee osteoarthritis. PRP was manufactured in Malaga’s Regional Blood Center (Spain). Patients that met the eligibility criteria were randomized into a PRP group or a HA group. Pain and functional improvements were assessed pre- and post-treatment (three and six months follow-up) using the Visual Analogue Scale (VAS); the Knee and Osteoarthritis Outcome System (KOOS) scale and the European Quality of Life scale (EUROQOL). Both groups presented pain reduction at six months. The VAS scores for the PRP group improved by at least 50% from their initial value, particularly at three months following the final infiltration, with results resembling those of the HA group at six months. PRP was more effective in patients with lower osteoarthritis grades. Both treatments improved pain in knee osteoarthritis patients without statistically significant differences between them. However, PRP injection was proved to improve pain three months after the final infiltration and to be more effective in lower osteoarthritis grades.
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spelling pubmed-49644402016-08-03 Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System Montañez-Heredia, Elvira Irízar, Sofia Huertas, Pedro J. Otero, Esperanza del Valle, Marta Prat, Isidro Díaz-Gallardo, Macarena S. Perán, Macarena Marchal, Juan A. Hernandez-Lamas, María del Carmen Int J Mol Sci Article Intra-articular injection of platelet-rich plasma (PRP) has been established as a suitable treatment for knee osteoarthritis. Here, we present a double-blind randomized controlled clinical trial, conducted in a public Hospital of the Spanish National Health Care System, to evaluate the efficacy of injecting autologous PRP versus hyaluronic acid (HA) in knee osteoarthritis. PRP was manufactured in Malaga’s Regional Blood Center (Spain). Patients that met the eligibility criteria were randomized into a PRP group or a HA group. Pain and functional improvements were assessed pre- and post-treatment (three and six months follow-up) using the Visual Analogue Scale (VAS); the Knee and Osteoarthritis Outcome System (KOOS) scale and the European Quality of Life scale (EUROQOL). Both groups presented pain reduction at six months. The VAS scores for the PRP group improved by at least 50% from their initial value, particularly at three months following the final infiltration, with results resembling those of the HA group at six months. PRP was more effective in patients with lower osteoarthritis grades. Both treatments improved pain in knee osteoarthritis patients without statistically significant differences between them. However, PRP injection was proved to improve pain three months after the final infiltration and to be more effective in lower osteoarthritis grades. MDPI 2016-07-02 /pmc/articles/PMC4964440/ /pubmed/27384560 http://dx.doi.org/10.3390/ijms17071064 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Montañez-Heredia, Elvira
Irízar, Sofia
Huertas, Pedro J.
Otero, Esperanza
del Valle, Marta
Prat, Isidro
Díaz-Gallardo, Macarena S.
Perán, Macarena
Marchal, Juan A.
Hernandez-Lamas, María del Carmen
Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System
title Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System
title_full Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System
title_fullStr Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System
title_full_unstemmed Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System
title_short Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System
title_sort intra-articular injections of platelet-rich plasma versus hyaluronic acid in the treatment of osteoarthritic knee pain: a randomized clinical trial in the context of the spanish national health care system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964440/
https://www.ncbi.nlm.nih.gov/pubmed/27384560
http://dx.doi.org/10.3390/ijms17071064
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