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The Prognostic and Predictive Role of Epidermal Growth Factor Receptor in Surgical Resected Pancreatic Cancer

The data regarding the prognostic significance of EGFR (epidermal growth factor receptor) expression and adjuvant therapy in patients with resected pancreatic cancer are insufficient. We retrospectively investigated EGFR status in 357 resected PDAC (pancreatic duct adenocarcinoma) patients using tis...

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Autores principales: Guo, Meng, Luo, Guopei, Liu, Chen, Cheng, He, Lu, Yu, Jin, Kaizhou, Liu, Zuqiang, Long, Jiang, Liu, Liang, Xu, Jin, Huang, Dan, Ni, Quanxing, Yu, Xianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964466/
https://www.ncbi.nlm.nih.gov/pubmed/27399694
http://dx.doi.org/10.3390/ijms17071090
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author Guo, Meng
Luo, Guopei
Liu, Chen
Cheng, He
Lu, Yu
Jin, Kaizhou
Liu, Zuqiang
Long, Jiang
Liu, Liang
Xu, Jin
Huang, Dan
Ni, Quanxing
Yu, Xianjun
author_facet Guo, Meng
Luo, Guopei
Liu, Chen
Cheng, He
Lu, Yu
Jin, Kaizhou
Liu, Zuqiang
Long, Jiang
Liu, Liang
Xu, Jin
Huang, Dan
Ni, Quanxing
Yu, Xianjun
author_sort Guo, Meng
collection PubMed
description The data regarding the prognostic significance of EGFR (epidermal growth factor receptor) expression and adjuvant therapy in patients with resected pancreatic cancer are insufficient. We retrospectively investigated EGFR status in 357 resected PDAC (pancreatic duct adenocarcinoma) patients using tissue immunohistochemistry and validated the possible role of EGFR expression in predicting prognosis. The analysis was based on excluding the multiple confounding parameters. A negative association was found between overall EGFR status and postoperative survival (p = 0.986). Remarkably, adjuvant chemotherapy and radiotherapy were significantly associated with favorable postoperative survival, which prolonged median overall survival (OS) for 5.8 and 10.2 months (p = 0.009 and p = 0.006, respectively). Kaplan–Meier analysis showed that adjuvant chemotherapy correlated with an obvious survival benefit in the EGFR-positive subgroup rather than in the EGFR-negative subgroup. In the subgroup analyses, chemotherapy was highly associated with increased postoperative survival in the EGFR-positive subgroup (p = 0.002), and radiotherapy had a significant survival benefit in the EGFR-negative subgroup (p = 0.029). This study demonstrated that EGFR expression is not correlated with outcome in resected pancreatic cancer patients. Adjuvant chemotherapy and radiotherapy were significantly associated with improved survival in contrary EGFR expressing subgroup. Further studies of EGFR as a potential target for pancreatic cancer treatment are warranted.
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spelling pubmed-49644662016-08-03 The Prognostic and Predictive Role of Epidermal Growth Factor Receptor in Surgical Resected Pancreatic Cancer Guo, Meng Luo, Guopei Liu, Chen Cheng, He Lu, Yu Jin, Kaizhou Liu, Zuqiang Long, Jiang Liu, Liang Xu, Jin Huang, Dan Ni, Quanxing Yu, Xianjun Int J Mol Sci Article The data regarding the prognostic significance of EGFR (epidermal growth factor receptor) expression and adjuvant therapy in patients with resected pancreatic cancer are insufficient. We retrospectively investigated EGFR status in 357 resected PDAC (pancreatic duct adenocarcinoma) patients using tissue immunohistochemistry and validated the possible role of EGFR expression in predicting prognosis. The analysis was based on excluding the multiple confounding parameters. A negative association was found between overall EGFR status and postoperative survival (p = 0.986). Remarkably, adjuvant chemotherapy and radiotherapy were significantly associated with favorable postoperative survival, which prolonged median overall survival (OS) for 5.8 and 10.2 months (p = 0.009 and p = 0.006, respectively). Kaplan–Meier analysis showed that adjuvant chemotherapy correlated with an obvious survival benefit in the EGFR-positive subgroup rather than in the EGFR-negative subgroup. In the subgroup analyses, chemotherapy was highly associated with increased postoperative survival in the EGFR-positive subgroup (p = 0.002), and radiotherapy had a significant survival benefit in the EGFR-negative subgroup (p = 0.029). This study demonstrated that EGFR expression is not correlated with outcome in resected pancreatic cancer patients. Adjuvant chemotherapy and radiotherapy were significantly associated with improved survival in contrary EGFR expressing subgroup. Further studies of EGFR as a potential target for pancreatic cancer treatment are warranted. MDPI 2016-07-08 /pmc/articles/PMC4964466/ /pubmed/27399694 http://dx.doi.org/10.3390/ijms17071090 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guo, Meng
Luo, Guopei
Liu, Chen
Cheng, He
Lu, Yu
Jin, Kaizhou
Liu, Zuqiang
Long, Jiang
Liu, Liang
Xu, Jin
Huang, Dan
Ni, Quanxing
Yu, Xianjun
The Prognostic and Predictive Role of Epidermal Growth Factor Receptor in Surgical Resected Pancreatic Cancer
title The Prognostic and Predictive Role of Epidermal Growth Factor Receptor in Surgical Resected Pancreatic Cancer
title_full The Prognostic and Predictive Role of Epidermal Growth Factor Receptor in Surgical Resected Pancreatic Cancer
title_fullStr The Prognostic and Predictive Role of Epidermal Growth Factor Receptor in Surgical Resected Pancreatic Cancer
title_full_unstemmed The Prognostic and Predictive Role of Epidermal Growth Factor Receptor in Surgical Resected Pancreatic Cancer
title_short The Prognostic and Predictive Role of Epidermal Growth Factor Receptor in Surgical Resected Pancreatic Cancer
title_sort prognostic and predictive role of epidermal growth factor receptor in surgical resected pancreatic cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964466/
https://www.ncbi.nlm.nih.gov/pubmed/27399694
http://dx.doi.org/10.3390/ijms17071090
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