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Environmental Factors Associated with Altered Gut Microbiota in Children with Eczema: A Systematic Review

Eczema is a common skin condition that impairs children’s daily life activities and quality of life. Previous research shows that gut microbiome composition plays an important role in the development of eczema. The present review summarizes evidence on environmental factors related to altered gut mi...

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Autores principales: Chan, Carmen W. H., Wong, Rosa S., Law, Patrick T. W., Wong, Cho Lee, Tsui, Stephen K. W., Tang, Winnie P. Y., Sit, Janet W. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964520/
https://www.ncbi.nlm.nih.gov/pubmed/27438825
http://dx.doi.org/10.3390/ijms17071147
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author Chan, Carmen W. H.
Wong, Rosa S.
Law, Patrick T. W.
Wong, Cho Lee
Tsui, Stephen K. W.
Tang, Winnie P. Y.
Sit, Janet W. H.
author_facet Chan, Carmen W. H.
Wong, Rosa S.
Law, Patrick T. W.
Wong, Cho Lee
Tsui, Stephen K. W.
Tang, Winnie P. Y.
Sit, Janet W. H.
author_sort Chan, Carmen W. H.
collection PubMed
description Eczema is a common skin condition that impairs children’s daily life activities and quality of life. Previous research shows that gut microbiome composition plays an important role in the development of eczema. The present review summarizes evidence on environmental factors related to altered gut microbiota in children with eczema. We searched Medline, PubMed, Embase, and the Cochrane database of Systematic Reviews through October 2015. The search strategy focused on articles published in peer-reviewed, English-language journals with no publication year limit. Only original studies and review articles that reported environmental factors on gut microbiome specific to eczema were included in this review. We selected six studies (total 1990 participants) for full review and identified that the composition of gut microbiota specific to eczema could be influenced by the following environmental factors: length of gestation, mode of delivery, type of feeding, method of treatment, number of older siblings, and other lifestyle factors. There has been inconsistent empirical evidence as to the modulatory effects of gut microbiota on immunological functions in children with eczema. Further research on the environmental-host-microbial interaction is needed to develop a strong base of knowledge for the development and implementation of prevention strategies and policies for eczema.
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spelling pubmed-49645202016-08-03 Environmental Factors Associated with Altered Gut Microbiota in Children with Eczema: A Systematic Review Chan, Carmen W. H. Wong, Rosa S. Law, Patrick T. W. Wong, Cho Lee Tsui, Stephen K. W. Tang, Winnie P. Y. Sit, Janet W. H. Int J Mol Sci Review Eczema is a common skin condition that impairs children’s daily life activities and quality of life. Previous research shows that gut microbiome composition plays an important role in the development of eczema. The present review summarizes evidence on environmental factors related to altered gut microbiota in children with eczema. We searched Medline, PubMed, Embase, and the Cochrane database of Systematic Reviews through October 2015. The search strategy focused on articles published in peer-reviewed, English-language journals with no publication year limit. Only original studies and review articles that reported environmental factors on gut microbiome specific to eczema were included in this review. We selected six studies (total 1990 participants) for full review and identified that the composition of gut microbiota specific to eczema could be influenced by the following environmental factors: length of gestation, mode of delivery, type of feeding, method of treatment, number of older siblings, and other lifestyle factors. There has been inconsistent empirical evidence as to the modulatory effects of gut microbiota on immunological functions in children with eczema. Further research on the environmental-host-microbial interaction is needed to develop a strong base of knowledge for the development and implementation of prevention strategies and policies for eczema. MDPI 2016-07-16 /pmc/articles/PMC4964520/ /pubmed/27438825 http://dx.doi.org/10.3390/ijms17071147 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chan, Carmen W. H.
Wong, Rosa S.
Law, Patrick T. W.
Wong, Cho Lee
Tsui, Stephen K. W.
Tang, Winnie P. Y.
Sit, Janet W. H.
Environmental Factors Associated with Altered Gut Microbiota in Children with Eczema: A Systematic Review
title Environmental Factors Associated with Altered Gut Microbiota in Children with Eczema: A Systematic Review
title_full Environmental Factors Associated with Altered Gut Microbiota in Children with Eczema: A Systematic Review
title_fullStr Environmental Factors Associated with Altered Gut Microbiota in Children with Eczema: A Systematic Review
title_full_unstemmed Environmental Factors Associated with Altered Gut Microbiota in Children with Eczema: A Systematic Review
title_short Environmental Factors Associated with Altered Gut Microbiota in Children with Eczema: A Systematic Review
title_sort environmental factors associated with altered gut microbiota in children with eczema: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964520/
https://www.ncbi.nlm.nih.gov/pubmed/27438825
http://dx.doi.org/10.3390/ijms17071147
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