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Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation

Aquaporins (AQPs) play important roles in the water transport system in the human body. There are currently 13 types of AQP, AQP0 through AQP12, which are expressed in various organs. Many members of the AQP family are expressed in the intestinal tract. AQP3 is predominantly expressed in the colon,...

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Autores principales: Ikarashi, Nobutomo, Kon, Risako, Sugiyama, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964543/
https://www.ncbi.nlm.nih.gov/pubmed/27447626
http://dx.doi.org/10.3390/ijms17071172
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author Ikarashi, Nobutomo
Kon, Risako
Sugiyama, Kiyoshi
author_facet Ikarashi, Nobutomo
Kon, Risako
Sugiyama, Kiyoshi
author_sort Ikarashi, Nobutomo
collection PubMed
description Aquaporins (AQPs) play important roles in the water transport system in the human body. There are currently 13 types of AQP, AQP0 through AQP12, which are expressed in various organs. Many members of the AQP family are expressed in the intestinal tract. AQP3 is predominantly expressed in the colon, ultimately controlling the water transport. Recently, it was clarified that several laxatives exhibit a laxative effect by changing the AQP3 expression level in the colon. In addition, it was revealed that morphine causes severe constipation by increasing the AQP3 expression level in the colon. These findings have shown that AQP3 is one of the most important functional molecules in water transport in the colon. This review will focus on the physiological and pathological roles of AQP3 in the colon, and discuss clinical applications of colon AQP3.
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spelling pubmed-49645432016-08-03 Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation Ikarashi, Nobutomo Kon, Risako Sugiyama, Kiyoshi Int J Mol Sci Review Aquaporins (AQPs) play important roles in the water transport system in the human body. There are currently 13 types of AQP, AQP0 through AQP12, which are expressed in various organs. Many members of the AQP family are expressed in the intestinal tract. AQP3 is predominantly expressed in the colon, ultimately controlling the water transport. Recently, it was clarified that several laxatives exhibit a laxative effect by changing the AQP3 expression level in the colon. In addition, it was revealed that morphine causes severe constipation by increasing the AQP3 expression level in the colon. These findings have shown that AQP3 is one of the most important functional molecules in water transport in the colon. This review will focus on the physiological and pathological roles of AQP3 in the colon, and discuss clinical applications of colon AQP3. MDPI 2016-07-20 /pmc/articles/PMC4964543/ /pubmed/27447626 http://dx.doi.org/10.3390/ijms17071172 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ikarashi, Nobutomo
Kon, Risako
Sugiyama, Kiyoshi
Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation
title Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation
title_full Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation
title_fullStr Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation
title_full_unstemmed Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation
title_short Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation
title_sort aquaporins in the colon as a new therapeutic target in diarrhea and constipation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964543/
https://www.ncbi.nlm.nih.gov/pubmed/27447626
http://dx.doi.org/10.3390/ijms17071172
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