Cargando…

Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR)

Nutrients play a fundamental role as regulators of the activity of enzymes involved in liver metabolism. In the general population, the action of nutrients may be affected by gene polymorphisms. Therefore, individualization of a diet for individuals with fatty liver seems to be a fundamental step in...

Descripción completa

Detalles Bibliográficos
Autores principales: Stachowska, Ewa, Ryterska, Karina, Maciejewska, Dominika, Banaszczak, Marcin, Milkiewicz, Piotr, Milkiewicz, Małgorzata, Gutowska, Izabela, Ossowski, Piotr, Kaczorowska, Małgorzata, Jamioł-Milc, Dominika, Sabinicz, Anna, Napierała, Małgorzata, Wądołowska, Lidia, Raszeja-Wyszomirska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964561/
https://www.ncbi.nlm.nih.gov/pubmed/27455252
http://dx.doi.org/10.3390/ijms17071192
_version_ 1782445138331566080
author Stachowska, Ewa
Ryterska, Karina
Maciejewska, Dominika
Banaszczak, Marcin
Milkiewicz, Piotr
Milkiewicz, Małgorzata
Gutowska, Izabela
Ossowski, Piotr
Kaczorowska, Małgorzata
Jamioł-Milc, Dominika
Sabinicz, Anna
Napierała, Małgorzata
Wądołowska, Lidia
Raszeja-Wyszomirska, Joanna
author_facet Stachowska, Ewa
Ryterska, Karina
Maciejewska, Dominika
Banaszczak, Marcin
Milkiewicz, Piotr
Milkiewicz, Małgorzata
Gutowska, Izabela
Ossowski, Piotr
Kaczorowska, Małgorzata
Jamioł-Milc, Dominika
Sabinicz, Anna
Napierała, Małgorzata
Wądołowska, Lidia
Raszeja-Wyszomirska, Joanna
author_sort Stachowska, Ewa
collection PubMed
description Nutrients play a fundamental role as regulators of the activity of enzymes involved in liver metabolism. In the general population, the action of nutrients may be affected by gene polymorphisms. Therefore, individualization of a diet for individuals with fatty liver seems to be a fundamental step in nutritional strategies. In this study, we tested the nutrient-induced insulin output ratio (NIOR), which is used to identify the correlation between the variants of genes and insulin resistance. We enrolled 171 patients, Caucasian men (n = 104) and women (n = 67), diagnosed with non-alcoholic fatty liver disease (NAFLD). From the pool of genes sensitive to nutrient content, we selected genes characterized by a strong response to the NIOR. The polymorphisms included Adrenergic receptor (b3AR), Tumor necrosis factor (TNFα), Apolipoprotein C (Apo C III). Uncoupling Protein type I (UCP-1), Peroxisome proliferator activated receptor γ2 (PPAR-2) and Apolipoprotein E (APOEs). We performed three dietary interventions: a diet consistent with the results of genotyping (NIOR (+)); typical dietary recommendations for NAFLD (Cust (+)), and a diet opposite to the genotyping results (NIOR (−) and Cust (−)). We administered the diet for six months. The most beneficial changes were observed among fat-sensitive patients who were treated with the NIOR (+) diet. These changes included improvements in body mass and insulin sensitivity and normalization of blood lipids. In people sensitive to fat, the NIOR seems to be a useful tool for determining specific strategies for the treatment of NAFLD.
format Online
Article
Text
id pubmed-4964561
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-49645612016-08-03 Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR) Stachowska, Ewa Ryterska, Karina Maciejewska, Dominika Banaszczak, Marcin Milkiewicz, Piotr Milkiewicz, Małgorzata Gutowska, Izabela Ossowski, Piotr Kaczorowska, Małgorzata Jamioł-Milc, Dominika Sabinicz, Anna Napierała, Małgorzata Wądołowska, Lidia Raszeja-Wyszomirska, Joanna Int J Mol Sci Article Nutrients play a fundamental role as regulators of the activity of enzymes involved in liver metabolism. In the general population, the action of nutrients may be affected by gene polymorphisms. Therefore, individualization of a diet for individuals with fatty liver seems to be a fundamental step in nutritional strategies. In this study, we tested the nutrient-induced insulin output ratio (NIOR), which is used to identify the correlation between the variants of genes and insulin resistance. We enrolled 171 patients, Caucasian men (n = 104) and women (n = 67), diagnosed with non-alcoholic fatty liver disease (NAFLD). From the pool of genes sensitive to nutrient content, we selected genes characterized by a strong response to the NIOR. The polymorphisms included Adrenergic receptor (b3AR), Tumor necrosis factor (TNFα), Apolipoprotein C (Apo C III). Uncoupling Protein type I (UCP-1), Peroxisome proliferator activated receptor γ2 (PPAR-2) and Apolipoprotein E (APOEs). We performed three dietary interventions: a diet consistent with the results of genotyping (NIOR (+)); typical dietary recommendations for NAFLD (Cust (+)), and a diet opposite to the genotyping results (NIOR (−) and Cust (−)). We administered the diet for six months. The most beneficial changes were observed among fat-sensitive patients who were treated with the NIOR (+) diet. These changes included improvements in body mass and insulin sensitivity and normalization of blood lipids. In people sensitive to fat, the NIOR seems to be a useful tool for determining specific strategies for the treatment of NAFLD. MDPI 2016-07-22 /pmc/articles/PMC4964561/ /pubmed/27455252 http://dx.doi.org/10.3390/ijms17071192 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stachowska, Ewa
Ryterska, Karina
Maciejewska, Dominika
Banaszczak, Marcin
Milkiewicz, Piotr
Milkiewicz, Małgorzata
Gutowska, Izabela
Ossowski, Piotr
Kaczorowska, Małgorzata
Jamioł-Milc, Dominika
Sabinicz, Anna
Napierała, Małgorzata
Wądołowska, Lidia
Raszeja-Wyszomirska, Joanna
Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR)
title Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR)
title_full Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR)
title_fullStr Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR)
title_full_unstemmed Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR)
title_short Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR)
title_sort nutritional strategies for the individualized treatment of non-alcoholic fatty liver disease (nafld) based on the nutrient-induced insulin output ratio (nior)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964561/
https://www.ncbi.nlm.nih.gov/pubmed/27455252
http://dx.doi.org/10.3390/ijms17071192
work_keys_str_mv AT stachowskaewa nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior
AT ryterskakarina nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior
AT maciejewskadominika nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior
AT banaszczakmarcin nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior
AT milkiewiczpiotr nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior
AT milkiewiczmałgorzata nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior
AT gutowskaizabela nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior
AT ossowskipiotr nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior
AT kaczorowskamałgorzata nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior
AT jamiołmilcdominika nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior
AT sabiniczanna nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior
AT napierałamałgorzata nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior
AT wadołowskalidia nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior
AT raszejawyszomirskajoanna nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior