Cargando…
Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR)
Nutrients play a fundamental role as regulators of the activity of enzymes involved in liver metabolism. In the general population, the action of nutrients may be affected by gene polymorphisms. Therefore, individualization of a diet for individuals with fatty liver seems to be a fundamental step in...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964561/ https://www.ncbi.nlm.nih.gov/pubmed/27455252 http://dx.doi.org/10.3390/ijms17071192 |
_version_ | 1782445138331566080 |
---|---|
author | Stachowska, Ewa Ryterska, Karina Maciejewska, Dominika Banaszczak, Marcin Milkiewicz, Piotr Milkiewicz, Małgorzata Gutowska, Izabela Ossowski, Piotr Kaczorowska, Małgorzata Jamioł-Milc, Dominika Sabinicz, Anna Napierała, Małgorzata Wądołowska, Lidia Raszeja-Wyszomirska, Joanna |
author_facet | Stachowska, Ewa Ryterska, Karina Maciejewska, Dominika Banaszczak, Marcin Milkiewicz, Piotr Milkiewicz, Małgorzata Gutowska, Izabela Ossowski, Piotr Kaczorowska, Małgorzata Jamioł-Milc, Dominika Sabinicz, Anna Napierała, Małgorzata Wądołowska, Lidia Raszeja-Wyszomirska, Joanna |
author_sort | Stachowska, Ewa |
collection | PubMed |
description | Nutrients play a fundamental role as regulators of the activity of enzymes involved in liver metabolism. In the general population, the action of nutrients may be affected by gene polymorphisms. Therefore, individualization of a diet for individuals with fatty liver seems to be a fundamental step in nutritional strategies. In this study, we tested the nutrient-induced insulin output ratio (NIOR), which is used to identify the correlation between the variants of genes and insulin resistance. We enrolled 171 patients, Caucasian men (n = 104) and women (n = 67), diagnosed with non-alcoholic fatty liver disease (NAFLD). From the pool of genes sensitive to nutrient content, we selected genes characterized by a strong response to the NIOR. The polymorphisms included Adrenergic receptor (b3AR), Tumor necrosis factor (TNFα), Apolipoprotein C (Apo C III). Uncoupling Protein type I (UCP-1), Peroxisome proliferator activated receptor γ2 (PPAR-2) and Apolipoprotein E (APOEs). We performed three dietary interventions: a diet consistent with the results of genotyping (NIOR (+)); typical dietary recommendations for NAFLD (Cust (+)), and a diet opposite to the genotyping results (NIOR (−) and Cust (−)). We administered the diet for six months. The most beneficial changes were observed among fat-sensitive patients who were treated with the NIOR (+) diet. These changes included improvements in body mass and insulin sensitivity and normalization of blood lipids. In people sensitive to fat, the NIOR seems to be a useful tool for determining specific strategies for the treatment of NAFLD. |
format | Online Article Text |
id | pubmed-4964561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49645612016-08-03 Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR) Stachowska, Ewa Ryterska, Karina Maciejewska, Dominika Banaszczak, Marcin Milkiewicz, Piotr Milkiewicz, Małgorzata Gutowska, Izabela Ossowski, Piotr Kaczorowska, Małgorzata Jamioł-Milc, Dominika Sabinicz, Anna Napierała, Małgorzata Wądołowska, Lidia Raszeja-Wyszomirska, Joanna Int J Mol Sci Article Nutrients play a fundamental role as regulators of the activity of enzymes involved in liver metabolism. In the general population, the action of nutrients may be affected by gene polymorphisms. Therefore, individualization of a diet for individuals with fatty liver seems to be a fundamental step in nutritional strategies. In this study, we tested the nutrient-induced insulin output ratio (NIOR), which is used to identify the correlation between the variants of genes and insulin resistance. We enrolled 171 patients, Caucasian men (n = 104) and women (n = 67), diagnosed with non-alcoholic fatty liver disease (NAFLD). From the pool of genes sensitive to nutrient content, we selected genes characterized by a strong response to the NIOR. The polymorphisms included Adrenergic receptor (b3AR), Tumor necrosis factor (TNFα), Apolipoprotein C (Apo C III). Uncoupling Protein type I (UCP-1), Peroxisome proliferator activated receptor γ2 (PPAR-2) and Apolipoprotein E (APOEs). We performed three dietary interventions: a diet consistent with the results of genotyping (NIOR (+)); typical dietary recommendations for NAFLD (Cust (+)), and a diet opposite to the genotyping results (NIOR (−) and Cust (−)). We administered the diet for six months. The most beneficial changes were observed among fat-sensitive patients who were treated with the NIOR (+) diet. These changes included improvements in body mass and insulin sensitivity and normalization of blood lipids. In people sensitive to fat, the NIOR seems to be a useful tool for determining specific strategies for the treatment of NAFLD. MDPI 2016-07-22 /pmc/articles/PMC4964561/ /pubmed/27455252 http://dx.doi.org/10.3390/ijms17071192 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Stachowska, Ewa Ryterska, Karina Maciejewska, Dominika Banaszczak, Marcin Milkiewicz, Piotr Milkiewicz, Małgorzata Gutowska, Izabela Ossowski, Piotr Kaczorowska, Małgorzata Jamioł-Milc, Dominika Sabinicz, Anna Napierała, Małgorzata Wądołowska, Lidia Raszeja-Wyszomirska, Joanna Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR) |
title | Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR) |
title_full | Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR) |
title_fullStr | Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR) |
title_full_unstemmed | Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR) |
title_short | Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR) |
title_sort | nutritional strategies for the individualized treatment of non-alcoholic fatty liver disease (nafld) based on the nutrient-induced insulin output ratio (nior) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964561/ https://www.ncbi.nlm.nih.gov/pubmed/27455252 http://dx.doi.org/10.3390/ijms17071192 |
work_keys_str_mv | AT stachowskaewa nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior AT ryterskakarina nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior AT maciejewskadominika nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior AT banaszczakmarcin nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior AT milkiewiczpiotr nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior AT milkiewiczmałgorzata nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior AT gutowskaizabela nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior AT ossowskipiotr nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior AT kaczorowskamałgorzata nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior AT jamiołmilcdominika nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior AT sabiniczanna nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior AT napierałamałgorzata nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior AT wadołowskalidia nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior AT raszejawyszomirskajoanna nutritionalstrategiesfortheindividualizedtreatmentofnonalcoholicfattyliverdiseasenafldbasedonthenutrientinducedinsulinoutputrationior |