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Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes

We assessed 1-year outcomes in patients with atrial fibrillation enrolled in the EurObservational Research Programme AF General Pilot Registry (EORP-AF), in relation to kidney function, as assessed by glomerular filtration rate (eGFR). In a cohort of 2398 patients (median age 69 years; 61% male), eG...

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Autores principales: Boriani, Giuseppe, Laroche, Cécile, Diemberger, Igor, Popescu, Mircea Ioachim, Rasmussen, Lars Hvilsted, Petrescu, Lucian, Crijns, Harry J. G. M., Tavazzi, Luigi, Maggioni, Aldo P., Lip, Gregory Y. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964613/
https://www.ncbi.nlm.nih.gov/pubmed/27466080
http://dx.doi.org/10.1038/srep30271
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author Boriani, Giuseppe
Laroche, Cécile
Diemberger, Igor
Popescu, Mircea Ioachim
Rasmussen, Lars Hvilsted
Petrescu, Lucian
Crijns, Harry J. G. M.
Tavazzi, Luigi
Maggioni, Aldo P.
Lip, Gregory Y. H.
author_facet Boriani, Giuseppe
Laroche, Cécile
Diemberger, Igor
Popescu, Mircea Ioachim
Rasmussen, Lars Hvilsted
Petrescu, Lucian
Crijns, Harry J. G. M.
Tavazzi, Luigi
Maggioni, Aldo P.
Lip, Gregory Y. H.
author_sort Boriani, Giuseppe
collection PubMed
description We assessed 1-year outcomes in patients with atrial fibrillation enrolled in the EurObservational Research Programme AF General Pilot Registry (EORP-AF), in relation to kidney function, as assessed by glomerular filtration rate (eGFR). In a cohort of 2398 patients (median age 69 years; 61% male), eGFR (ml/min/1.73 m(2)) calculated using the CKD-EPI formula was ≥80 in 35.1%, 50–79 in 47.2%, 30–49 in 13.9% and <30 in 3.7% of patients. In a logistic regression analysis, eGFR category was an independent predictor of stroke/TIA or death, with elevated odds ratios associated with severe to mild renal impairment, ie. eGFR < 30 ml/min/1.73 m(2) [OR 3.641, 95% CI 1.572–8.433, p < 0.0001], 30–49 ml/min/1.73 m(2) [OR 3.303, 95% CI 1.740–6.270, p = 0.0026] or 50–79 ml/min/1.73 m2 [OR 2.094, 95% CI 1.194–3.672, p = 0.0003]. The discriminant capability for the risk of death was tested among various eGFR calculation algorithms: the best was the Cockcroft-Gault equation adjusted for BSA, followed by Cockcroft-Gault equation, and CKD-EPI equation, while the worst was the MDRD equation. In conclusion in this prospective observational registry, renal function was a major determinant of adverse outcomes at 1 year, and even mild or moderate renal impairments were associated with an increased risk of stroke/TIA/death.
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spelling pubmed-49646132016-08-08 Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes Boriani, Giuseppe Laroche, Cécile Diemberger, Igor Popescu, Mircea Ioachim Rasmussen, Lars Hvilsted Petrescu, Lucian Crijns, Harry J. G. M. Tavazzi, Luigi Maggioni, Aldo P. Lip, Gregory Y. H. Sci Rep Article We assessed 1-year outcomes in patients with atrial fibrillation enrolled in the EurObservational Research Programme AF General Pilot Registry (EORP-AF), in relation to kidney function, as assessed by glomerular filtration rate (eGFR). In a cohort of 2398 patients (median age 69 years; 61% male), eGFR (ml/min/1.73 m(2)) calculated using the CKD-EPI formula was ≥80 in 35.1%, 50–79 in 47.2%, 30–49 in 13.9% and <30 in 3.7% of patients. In a logistic regression analysis, eGFR category was an independent predictor of stroke/TIA or death, with elevated odds ratios associated with severe to mild renal impairment, ie. eGFR < 30 ml/min/1.73 m(2) [OR 3.641, 95% CI 1.572–8.433, p < 0.0001], 30–49 ml/min/1.73 m(2) [OR 3.303, 95% CI 1.740–6.270, p = 0.0026] or 50–79 ml/min/1.73 m2 [OR 2.094, 95% CI 1.194–3.672, p = 0.0003]. The discriminant capability for the risk of death was tested among various eGFR calculation algorithms: the best was the Cockcroft-Gault equation adjusted for BSA, followed by Cockcroft-Gault equation, and CKD-EPI equation, while the worst was the MDRD equation. In conclusion in this prospective observational registry, renal function was a major determinant of adverse outcomes at 1 year, and even mild or moderate renal impairments were associated with an increased risk of stroke/TIA/death. Nature Publishing Group 2016-07-28 /pmc/articles/PMC4964613/ /pubmed/27466080 http://dx.doi.org/10.1038/srep30271 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Boriani, Giuseppe
Laroche, Cécile
Diemberger, Igor
Popescu, Mircea Ioachim
Rasmussen, Lars Hvilsted
Petrescu, Lucian
Crijns, Harry J. G. M.
Tavazzi, Luigi
Maggioni, Aldo P.
Lip, Gregory Y. H.
Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes
title Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes
title_full Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes
title_fullStr Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes
title_full_unstemmed Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes
title_short Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes
title_sort glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964613/
https://www.ncbi.nlm.nih.gov/pubmed/27466080
http://dx.doi.org/10.1038/srep30271
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