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Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes
We assessed 1-year outcomes in patients with atrial fibrillation enrolled in the EurObservational Research Programme AF General Pilot Registry (EORP-AF), in relation to kidney function, as assessed by glomerular filtration rate (eGFR). In a cohort of 2398 patients (median age 69 years; 61% male), eG...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964613/ https://www.ncbi.nlm.nih.gov/pubmed/27466080 http://dx.doi.org/10.1038/srep30271 |
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author | Boriani, Giuseppe Laroche, Cécile Diemberger, Igor Popescu, Mircea Ioachim Rasmussen, Lars Hvilsted Petrescu, Lucian Crijns, Harry J. G. M. Tavazzi, Luigi Maggioni, Aldo P. Lip, Gregory Y. H. |
author_facet | Boriani, Giuseppe Laroche, Cécile Diemberger, Igor Popescu, Mircea Ioachim Rasmussen, Lars Hvilsted Petrescu, Lucian Crijns, Harry J. G. M. Tavazzi, Luigi Maggioni, Aldo P. Lip, Gregory Y. H. |
author_sort | Boriani, Giuseppe |
collection | PubMed |
description | We assessed 1-year outcomes in patients with atrial fibrillation enrolled in the EurObservational Research Programme AF General Pilot Registry (EORP-AF), in relation to kidney function, as assessed by glomerular filtration rate (eGFR). In a cohort of 2398 patients (median age 69 years; 61% male), eGFR (ml/min/1.73 m(2)) calculated using the CKD-EPI formula was ≥80 in 35.1%, 50–79 in 47.2%, 30–49 in 13.9% and <30 in 3.7% of patients. In a logistic regression analysis, eGFR category was an independent predictor of stroke/TIA or death, with elevated odds ratios associated with severe to mild renal impairment, ie. eGFR < 30 ml/min/1.73 m(2) [OR 3.641, 95% CI 1.572–8.433, p < 0.0001], 30–49 ml/min/1.73 m(2) [OR 3.303, 95% CI 1.740–6.270, p = 0.0026] or 50–79 ml/min/1.73 m2 [OR 2.094, 95% CI 1.194–3.672, p = 0.0003]. The discriminant capability for the risk of death was tested among various eGFR calculation algorithms: the best was the Cockcroft-Gault equation adjusted for BSA, followed by Cockcroft-Gault equation, and CKD-EPI equation, while the worst was the MDRD equation. In conclusion in this prospective observational registry, renal function was a major determinant of adverse outcomes at 1 year, and even mild or moderate renal impairments were associated with an increased risk of stroke/TIA/death. |
format | Online Article Text |
id | pubmed-4964613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49646132016-08-08 Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes Boriani, Giuseppe Laroche, Cécile Diemberger, Igor Popescu, Mircea Ioachim Rasmussen, Lars Hvilsted Petrescu, Lucian Crijns, Harry J. G. M. Tavazzi, Luigi Maggioni, Aldo P. Lip, Gregory Y. H. Sci Rep Article We assessed 1-year outcomes in patients with atrial fibrillation enrolled in the EurObservational Research Programme AF General Pilot Registry (EORP-AF), in relation to kidney function, as assessed by glomerular filtration rate (eGFR). In a cohort of 2398 patients (median age 69 years; 61% male), eGFR (ml/min/1.73 m(2)) calculated using the CKD-EPI formula was ≥80 in 35.1%, 50–79 in 47.2%, 30–49 in 13.9% and <30 in 3.7% of patients. In a logistic regression analysis, eGFR category was an independent predictor of stroke/TIA or death, with elevated odds ratios associated with severe to mild renal impairment, ie. eGFR < 30 ml/min/1.73 m(2) [OR 3.641, 95% CI 1.572–8.433, p < 0.0001], 30–49 ml/min/1.73 m(2) [OR 3.303, 95% CI 1.740–6.270, p = 0.0026] or 50–79 ml/min/1.73 m2 [OR 2.094, 95% CI 1.194–3.672, p = 0.0003]. The discriminant capability for the risk of death was tested among various eGFR calculation algorithms: the best was the Cockcroft-Gault equation adjusted for BSA, followed by Cockcroft-Gault equation, and CKD-EPI equation, while the worst was the MDRD equation. In conclusion in this prospective observational registry, renal function was a major determinant of adverse outcomes at 1 year, and even mild or moderate renal impairments were associated with an increased risk of stroke/TIA/death. Nature Publishing Group 2016-07-28 /pmc/articles/PMC4964613/ /pubmed/27466080 http://dx.doi.org/10.1038/srep30271 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Boriani, Giuseppe Laroche, Cécile Diemberger, Igor Popescu, Mircea Ioachim Rasmussen, Lars Hvilsted Petrescu, Lucian Crijns, Harry J. G. M. Tavazzi, Luigi Maggioni, Aldo P. Lip, Gregory Y. H. Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes |
title | Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes |
title_full | Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes |
title_fullStr | Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes |
title_full_unstemmed | Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes |
title_short | Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes |
title_sort | glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964613/ https://www.ncbi.nlm.nih.gov/pubmed/27466080 http://dx.doi.org/10.1038/srep30271 |
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