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Depression in Chinese patients with type 2 diabetes: associations with hyperglycemia, hypoglycemia, and poor treatment adherence: 中国人2型糖尿病抑郁情况及其与高血糖、低血糖及治疗依从性关系的研究

BACKGROUND: We hypothesize that depression in type 2 diabetes might be associated with poor glycemic control, in part due to suboptimal self‐care. We tested this hypothesis by examining the associations of depression with clinical and laboratory findings in a multicenter survey of Chinese type 2 dia...

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Autores principales: Zhang, Yuying, Ting, Rose ZW, Yang, Wenying, Jia, Weiping, Li, Wenhui, Ji, Linong, Guo, Xiaohui, Kong, Alice PS, Wing, Yun‐Kwok, Luk, Andrea OY, Sartorius, Norman, Morisky, Donald E, Oldenburg, Brian, Weng, Jianping, Chan, Juliana CN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964948/
https://www.ncbi.nlm.nih.gov/pubmed/25349949
http://dx.doi.org/10.1111/1753-0407.12238
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author Zhang, Yuying
Ting, Rose ZW
Yang, Wenying
Jia, Weiping
Li, Wenhui
Ji, Linong
Guo, Xiaohui
Kong, Alice PS
Wing, Yun‐Kwok
Luk, Andrea OY
Sartorius, Norman
Morisky, Donald E
Oldenburg, Brian
Weng, Jianping
Chan, Juliana CN
author_facet Zhang, Yuying
Ting, Rose ZW
Yang, Wenying
Jia, Weiping
Li, Wenhui
Ji, Linong
Guo, Xiaohui
Kong, Alice PS
Wing, Yun‐Kwok
Luk, Andrea OY
Sartorius, Norman
Morisky, Donald E
Oldenburg, Brian
Weng, Jianping
Chan, Juliana CN
author_sort Zhang, Yuying
collection PubMed
description BACKGROUND: We hypothesize that depression in type 2 diabetes might be associated with poor glycemic control, in part due to suboptimal self‐care. We tested this hypothesis by examining the associations of depression with clinical and laboratory findings in a multicenter survey of Chinese type 2 diabetic patients. METHOD: 2538 patients aged 18–75 years attending hospital‐based clinics in four cities in China underwent detailed clinical‐psychological‐behavioral assessment during a 12‐month period between 2011 and 2012. Depression was diagnosed if Patient Health Questionnaire‐9 (PHQ‐9) score ≥10. Diabetes self‐care and medication adherence were assessed using the Summary of Diabetes Self‐care Activities and the 4‐item Morisky medication adherence scale respectively. RESULTS: In this cross‐sectional study (mean age: 56.4 ± 10.5[SD] years, 53% men), 6.1% (n = 155) had depression. After controlling for study sites, patients with depression had higher HbA (1c) (7.9 ± 2.0 vs. 7.7 ± 2.0%, P = 0.008) and were less likely to achieve HbA (1c) goal of <7.0% (36.2% vs 45.6%, P = 0.004) than those without depression. They were more likely to report hypoglycemia and to have fewer days of being adherent to their recommended diet, exercise, foot care and medication. In logistic regression, apart from young age, poor education, long disease duration, tobacco use, high body mass index, use of insulin, depression was independently associated with failure to attain HbA (1c) target (Odds Ratio [OR] = 1.56, 95%CI:1.05–2.32, P = 0.028). The association between depression and glycemic control became non‐significant after inclusion of adherence to diet, exercise and medication (OR = 1.48, 95% CI 0.99–2.21, P = 0.058). CONCLUSION: Depression in type 2 diabetes was closely associated with hyperglycemia and hypoglycemia, which might be partly mediated through poor treatment adherence.
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spelling pubmed-49649482016-08-11 Depression in Chinese patients with type 2 diabetes: associations with hyperglycemia, hypoglycemia, and poor treatment adherence: 中国人2型糖尿病抑郁情况及其与高血糖、低血糖及治疗依从性关系的研究 Zhang, Yuying Ting, Rose ZW Yang, Wenying Jia, Weiping Li, Wenhui Ji, Linong Guo, Xiaohui Kong, Alice PS Wing, Yun‐Kwok Luk, Andrea OY Sartorius, Norman Morisky, Donald E Oldenburg, Brian Weng, Jianping Chan, Juliana CN J Diabetes Original Articles BACKGROUND: We hypothesize that depression in type 2 diabetes might be associated with poor glycemic control, in part due to suboptimal self‐care. We tested this hypothesis by examining the associations of depression with clinical and laboratory findings in a multicenter survey of Chinese type 2 diabetic patients. METHOD: 2538 patients aged 18–75 years attending hospital‐based clinics in four cities in China underwent detailed clinical‐psychological‐behavioral assessment during a 12‐month period between 2011 and 2012. Depression was diagnosed if Patient Health Questionnaire‐9 (PHQ‐9) score ≥10. Diabetes self‐care and medication adherence were assessed using the Summary of Diabetes Self‐care Activities and the 4‐item Morisky medication adherence scale respectively. RESULTS: In this cross‐sectional study (mean age: 56.4 ± 10.5[SD] years, 53% men), 6.1% (n = 155) had depression. After controlling for study sites, patients with depression had higher HbA (1c) (7.9 ± 2.0 vs. 7.7 ± 2.0%, P = 0.008) and were less likely to achieve HbA (1c) goal of <7.0% (36.2% vs 45.6%, P = 0.004) than those without depression. They were more likely to report hypoglycemia and to have fewer days of being adherent to their recommended diet, exercise, foot care and medication. In logistic regression, apart from young age, poor education, long disease duration, tobacco use, high body mass index, use of insulin, depression was independently associated with failure to attain HbA (1c) target (Odds Ratio [OR] = 1.56, 95%CI:1.05–2.32, P = 0.028). The association between depression and glycemic control became non‐significant after inclusion of adherence to diet, exercise and medication (OR = 1.48, 95% CI 0.99–2.21, P = 0.058). CONCLUSION: Depression in type 2 diabetes was closely associated with hyperglycemia and hypoglycemia, which might be partly mediated through poor treatment adherence. John Wiley and Sons Inc. 2015-02-19 2015-11 /pmc/articles/PMC4964948/ /pubmed/25349949 http://dx.doi.org/10.1111/1753-0407.12238 Text en © 2014 The Authors. Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Zhang, Yuying
Ting, Rose ZW
Yang, Wenying
Jia, Weiping
Li, Wenhui
Ji, Linong
Guo, Xiaohui
Kong, Alice PS
Wing, Yun‐Kwok
Luk, Andrea OY
Sartorius, Norman
Morisky, Donald E
Oldenburg, Brian
Weng, Jianping
Chan, Juliana CN
Depression in Chinese patients with type 2 diabetes: associations with hyperglycemia, hypoglycemia, and poor treatment adherence: 中国人2型糖尿病抑郁情况及其与高血糖、低血糖及治疗依从性关系的研究
title Depression in Chinese patients with type 2 diabetes: associations with hyperglycemia, hypoglycemia, and poor treatment adherence: 中国人2型糖尿病抑郁情况及其与高血糖、低血糖及治疗依从性关系的研究
title_full Depression in Chinese patients with type 2 diabetes: associations with hyperglycemia, hypoglycemia, and poor treatment adherence: 中国人2型糖尿病抑郁情况及其与高血糖、低血糖及治疗依从性关系的研究
title_fullStr Depression in Chinese patients with type 2 diabetes: associations with hyperglycemia, hypoglycemia, and poor treatment adherence: 中国人2型糖尿病抑郁情况及其与高血糖、低血糖及治疗依从性关系的研究
title_full_unstemmed Depression in Chinese patients with type 2 diabetes: associations with hyperglycemia, hypoglycemia, and poor treatment adherence: 中国人2型糖尿病抑郁情况及其与高血糖、低血糖及治疗依从性关系的研究
title_short Depression in Chinese patients with type 2 diabetes: associations with hyperglycemia, hypoglycemia, and poor treatment adherence: 中国人2型糖尿病抑郁情况及其与高血糖、低血糖及治疗依从性关系的研究
title_sort depression in chinese patients with type 2 diabetes: associations with hyperglycemia, hypoglycemia, and poor treatment adherence: 中国人2型糖尿病抑郁情况及其与高血糖、低血糖及治疗依从性关系的研究
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964948/
https://www.ncbi.nlm.nih.gov/pubmed/25349949
http://dx.doi.org/10.1111/1753-0407.12238
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