Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1

Shikonin is a highly lipophilic naphtoquinone found in the roots of Lithospermum erythrorhizon used for its pleiotropic effects in traditional Chinese medicine. Based on its reported antipyretic and anti-inflammatory properties, we investigated whether shikonin suppresses the activation of NLRP3 inf...

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Detalles Bibliográficos
Autores principales: Zorman, Jernej, Sušjan, Petra, Hafner-Bratkovič, Iva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965082/
https://www.ncbi.nlm.nih.gov/pubmed/27467658
http://dx.doi.org/10.1371/journal.pone.0159826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965082/
https://www.ncbi.nlm.nih.gov/pubmed/27467658
http://dx.doi.org/10.1371/journal.pone.0159826

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