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Transgenic Rescue of the LARGE(myd) Mouse: A LARGE Therapeutic Window?

LARGE is a glycosyltransferase involved in glycosylation of α-dystroglycan (α-DG). Absence of this protein in the LARGE(myd) mouse results in α-DG hypoglycosylation, and is associated with central nervous system abnormalities and progressive muscular dystrophy. Up-regulation of LARGE has previously...

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Detalles Bibliográficos
Autores principales: Hildyard, J. C. W., Lacey, E., Booler, H., Hopkinson, M., Wells, D. J., Brown, S. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965172/
https://www.ncbi.nlm.nih.gov/pubmed/27467128
http://dx.doi.org/10.1371/journal.pone.0159853

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