Cargando…

CD4(+) T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

Mycobacterium tuberculosis (Mtb), possesses at least three type VII secretion systems, ESX-1, -3 and -5 that are actively involved in pathogenesis and host-pathogen interaction. We recently showed that an attenuated Mtb vaccine candidate (Mtb Δppe25-pe19), which lacks the characteristic ESX-5-associ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sayes, Fadel, Pawlik, Alexandre, Frigui, Wafa, Gröschel, Matthias I., Crommelynck, Samuel, Fayolle, Catherine, Cia, Felipe, Bancroft, Gregory J., Bottai, Daria, Leclerc, Claude, Brosch, Roland, Majlessi, Laleh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965174/ https://www.ncbi.nlm.nih.gov/pubmed/27467705 http://dx.doi.org/10.1371/journal.ppat.1005770

Ejemplares similares

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection
por: Ates, Louis S., et al.
Publicado: (2018)

Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis
por: Le Chevalier, Fabien, et al.
Publicado: (2015)

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors
por: Sayes, Fadel, et al.
Publicado: (2018)

Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo
por: Simeone, Roxane, et al.
Publicado: (2015)

Control of M. tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP
por: Frigui, Wafa, et al.
Publicado: (2008)

Mycobacterial virulence: impact on immunogenicity and vaccine research
por: Kroesen, Vera M., et al.
Publicado: (2019)

TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages
por: Bottai, Daria, et al.
Publicado: (2020)

Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity
por: Ates, Louis S, et al.
Publicado: (2018)

Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential
por: Pérez, Irene, et al.
Publicado: (2020)

PE11, a PE/PPE family protein of Mycobacterium tuberculosis is involved in cell wall remodeling and virulence
por: Singh, Parul, et al.
Publicado: (2016)

Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
por: Phelan, Jody E., et al.
Publicado: (2016)

Immunological effects of the PE/PPE family proteins of Mycobacterium tuberculosis and related vaccines
por: Guo, Fangzheng, et al.
Publicado: (2023)

Effect of Attenuation of Treg during BCG Immunization on Anti-Mycobacterial Th1 Responses and Protection against Mycobacterium tuberculosis
por: Jaron, Barbara, et al.
Publicado: (2008)

WhiB4 Regulates the PE/PPE Gene Family and is Essential for Virulence of Mycobacterium marinum
por: Wu, Jing, et al.
Publicado: (2017)

The Mycobacterium tuberculosis PE15/PPE20 complex transports calcium across the outer membrane
por: Boradia, Vishant, et al.
Publicado: (2022)

Phenotypic and genomic hallmarks of a novel, potentially pathogenic rapidly growing Mycobacterium species related to the Mycobacterium fortuitum complex
por: Gharbi, Reem, et al.
Publicado: (2021)

Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts
por: Orgeur, Mickael, et al.
Publicado: (2021)

Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface
por: Sampson, Samantha L.
Publicado: (2011)

Disorder‐to‐order transition in PE–PPE proteins of Mycobacterium tuberculosis augments the pro‐pathogen immune response
por: Ahmad, Javeed, et al.
Publicado: (2019)

283. Screening the PE/PPE secreted effectors of Mycobacterium tuberculosis to uncover novel virulence-promoting genes
por: Koleske, Benjamin, et al.
Publicado: (2023)

The Enigmatic PE/PPE Multigene Family of Mycobacteria and Tuberculosis Vaccination
por: Brennan, Michael J.
Publicado: (2017)

The PE-PPE Domain in Mycobacterium Reveals a Serine α/β Hydrolase Fold and Function: An In-Silico Analysis
por: Sultana, Rafiya, et al.
Publicado: (2011)

Mycobacterium tuberculosis PE/PPE proteins enhance the production of reactive oxygen species and formation of neutrophil extracellular traps
por: García-Bengoa, María, et al.
Publicado: (2023)

ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains
por: Madacki, Jan, et al.
Publicado: (2021)

Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death
por: Simeone, Roxane, et al.
Publicado: (2012)

Identifying Cognate Binding Pairs among a Large Set of Paralogs: The Case of PE/PPE Proteins of Mycobacterium tuberculosis
por: Riley, Robert, et al.
Publicado: (2008)

Comparative Analysis of Mycobacterium tuberculosis pe and ppe Genes Reveals High Sequence Variation and an Apparent Absence of Selective Constraints
por: McEvoy, Christopher R. E., et al.
Publicado: (2012)

Mycobacterium tuberculosis PE25/PPE41 protein complex induces necrosis in macrophages: Role in virulence and disease reactivation?
por: Tundup, Smanla, et al.
Publicado: (2014)

Functional genetic variation in pe/ppe genes contributes to diversity in Mycobacterium tuberculosis lineages and potential interactions with the human host
por: Gómez-González, Paula Josefina, et al.
Publicado: (2023)

Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions
por: Gey van Pittius, Nicolaas C, et al.
Publicado: (2006)

The Co-Operonic PE25/PPE41 Protein Complex of Mycobacterium tuberculosis Elicits Increased Humoral and Cell Mediated Immune Response
por: Tundup, Smanla, et al.
Publicado: (2008)

Mycobacterium tuberculosis Co-operonic PE32/PPE65 Proteins Alter Host Immune Responses by Hampering Th1 Response
por: Khubaib, Mohd, et al.
Publicado: (2016)

Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli
por: Malaga, Wladimir, et al.
Publicado: (2023)

New insights into the mycobacterial PE and PPE proteins provide a framework for future research
por: Ates, Louis S.
Publicado: (2019)

Conserved Immune Recognition Hierarchy of Mycobacterial PE/PPE Proteins during Infection in Natural Hosts
por: Vordermeier, H. Martin, et al.
Publicado: (2012)

Prediction of Certain Well-Characterized Domains of Known Functions within the PE and PPE Proteins of Mycobacteria
por: Sultana, Rafiya, et al.
Publicado: (2016)

PPE or not PPE - that is the question
por: D’Cruz, Len
Publicado: (2020)

Genome analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of the etiologic agent of tuberculosis
por: Supply, Philip, et al.
Publicado: (2013)

PPE51 Is Involved in the Uptake of Disaccharides by Mycobacterium tuberculosis
por: Korycka-Machała, Małgorzata, et al.
Publicado: (2020)

Mycobacterium PPE31 Contributes to Host Cell Death
por: Feng, Siyuan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_n9tjk8a8bnceum0e3746l09ojd