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Clinical Characteristics of Kawasaki Disease in Infants Younger than Six Months: A Single-Center Study
BACKGROUND AND OBJECTIVES: Kawasaki disease (KD) is the leading cause of acquired heart disease, which predominantly occurs in children under the age of 5 years. However, there are fewer cases of KD in infants younger than 6 months, which makes it difficult to diagnose. We investigated the clinical...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Cardiology
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965435/ https://www.ncbi.nlm.nih.gov/pubmed/27482265 http://dx.doi.org/10.4070/kcj.2016.46.4.550 |
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author | Yoon, You Min Yun, Hye Won Kim, Sung Hye |
author_facet | Yoon, You Min Yun, Hye Won Kim, Sung Hye |
author_sort | Yoon, You Min |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Kawasaki disease (KD) is the leading cause of acquired heart disease, which predominantly occurs in children under the age of 5 years. However, there are fewer cases of KD in infants younger than 6 months, which makes it difficult to diagnose. We investigated the clinical manifestations of KD in this age group and compared them with those in the older age group. SUBJECTS AND METHODS: We retrospectively reviewed the medical records of 239 patients with KD admitted to the Hallym Sacred Heart Hospital from January 2013 to June 2015. The data were categorized into 2 groups by age: Group A (≤6 months, n=26) and Group B (>6 months, n=213). RESULTS: Group A had a longer hospitalization period than Group B (6.69 vs. 5.19 days, p=0.002). Group A had fewer clinical manifestations upon admission, due to which there was a higher incidence of incomplete KD (1.88 vs. 3.54 of the diagnostic criteria, p<0.05; and 19.2% vs. 4.2% incomplete KD incidence, p=0.002). The rate of cardiac complications was higher in Group A (30.8% vs. 11.7%, p=0.011). CONCLUSION: The rate of cardiac complications of the patients younger than 6 months was significantly higher than that of the older patients. Therefore, infants younger than 6 months with unexplained fever for more than 5 days should be suspected as having KD, even if the principal clinical features are not fully presented. Echocardiography must be appropriately used for diagnosis of KD in suspected patients. |
format | Online Article Text |
id | pubmed-4965435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Society of Cardiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-49654352016-08-01 Clinical Characteristics of Kawasaki Disease in Infants Younger than Six Months: A Single-Center Study Yoon, You Min Yun, Hye Won Kim, Sung Hye Korean Circ J Original Article BACKGROUND AND OBJECTIVES: Kawasaki disease (KD) is the leading cause of acquired heart disease, which predominantly occurs in children under the age of 5 years. However, there are fewer cases of KD in infants younger than 6 months, which makes it difficult to diagnose. We investigated the clinical manifestations of KD in this age group and compared them with those in the older age group. SUBJECTS AND METHODS: We retrospectively reviewed the medical records of 239 patients with KD admitted to the Hallym Sacred Heart Hospital from January 2013 to June 2015. The data were categorized into 2 groups by age: Group A (≤6 months, n=26) and Group B (>6 months, n=213). RESULTS: Group A had a longer hospitalization period than Group B (6.69 vs. 5.19 days, p=0.002). Group A had fewer clinical manifestations upon admission, due to which there was a higher incidence of incomplete KD (1.88 vs. 3.54 of the diagnostic criteria, p<0.05; and 19.2% vs. 4.2% incomplete KD incidence, p=0.002). The rate of cardiac complications was higher in Group A (30.8% vs. 11.7%, p=0.011). CONCLUSION: The rate of cardiac complications of the patients younger than 6 months was significantly higher than that of the older patients. Therefore, infants younger than 6 months with unexplained fever for more than 5 days should be suspected as having KD, even if the principal clinical features are not fully presented. Echocardiography must be appropriately used for diagnosis of KD in suspected patients. The Korean Society of Cardiology 2016-07 2016-07-21 /pmc/articles/PMC4965435/ /pubmed/27482265 http://dx.doi.org/10.4070/kcj.2016.46.4.550 Text en Copyright © 2016 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yoon, You Min Yun, Hye Won Kim, Sung Hye Clinical Characteristics of Kawasaki Disease in Infants Younger than Six Months: A Single-Center Study |
title | Clinical Characteristics of Kawasaki Disease in Infants Younger than Six Months: A Single-Center Study |
title_full | Clinical Characteristics of Kawasaki Disease in Infants Younger than Six Months: A Single-Center Study |
title_fullStr | Clinical Characteristics of Kawasaki Disease in Infants Younger than Six Months: A Single-Center Study |
title_full_unstemmed | Clinical Characteristics of Kawasaki Disease in Infants Younger than Six Months: A Single-Center Study |
title_short | Clinical Characteristics of Kawasaki Disease in Infants Younger than Six Months: A Single-Center Study |
title_sort | clinical characteristics of kawasaki disease in infants younger than six months: a single-center study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965435/ https://www.ncbi.nlm.nih.gov/pubmed/27482265 http://dx.doi.org/10.4070/kcj.2016.46.4.550 |
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