Protective effects of heat-killed Lactococcus lactis subsp. lactis BF3, isolated from the intestine of chum salmon, in a murine model of DSS-induced inflammatory bowel disease

Oxidative stress is considered an etiological factor responsible for several symptoms of inflammatory bowel disease (IBD). In vitro anti-inflammatory activities of heat-killed Lactococcus lactis subsp. lactis BF3 have been reported. In this study, the anti-inflammatory effect of these cells was exam...

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Autores principales: NAKATA, Toru, HIRANO, Shino, YOKOTA, Yasushi, TAKAHASHI, Hajime, KIMURA, Bon, KUDA, Takashi, ETO, Tadashi, KATO, Michiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMFH Press 2016
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965518/
https://www.ncbi.nlm.nih.gov/pubmed/27508115
http://dx.doi.org/10.12938/bmfh.2016-007
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author NAKATA, Toru
HIRANO, Shino
YOKOTA, Yasushi
TAKAHASHI, Hajime
KIMURA, Bon
KUDA, Takashi
ETO, Tadashi
KATO, Michiko
author_facet NAKATA, Toru
HIRANO, Shino
YOKOTA, Yasushi
TAKAHASHI, Hajime
KIMURA, Bon
KUDA, Takashi
ETO, Tadashi
KATO, Michiko
author_sort NAKATA, Toru
collection PubMed
description Oxidative stress is considered an etiological factor responsible for several symptoms of inflammatory bowel disease (IBD). In vitro anti-inflammatory activities of heat-killed Lactococcus lactis subsp. lactis BF3 have been reported. In this study, the anti-inflammatory effect of these cells was examined using a dextran sodium sulphate (DSS)-induced murine IBD model. Administration of heat-killed L. lactis BF3 via drinking water suppressed the IBD symptoms, such as shortening of colon length, damage to the colon mucosa as observed under the microscope, and spleen enlargement. This result suggests that heat-killed L. lactis BF3 has the potential to treat IBD.
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spelling pubmed-49655182016-08-09 Protective effects of heat-killed Lactococcus lactis subsp. lactis BF3, isolated from the intestine of chum salmon, in a murine model of DSS-induced inflammatory bowel disease NAKATA, Toru HIRANO, Shino YOKOTA, Yasushi TAKAHASHI, Hajime KIMURA, Bon KUDA, Takashi ETO, Tadashi KATO, Michiko Biosci Microbiota Food Health Note Oxidative stress is considered an etiological factor responsible for several symptoms of inflammatory bowel disease (IBD). In vitro anti-inflammatory activities of heat-killed Lactococcus lactis subsp. lactis BF3 have been reported. In this study, the anti-inflammatory effect of these cells was examined using a dextran sodium sulphate (DSS)-induced murine IBD model. Administration of heat-killed L. lactis BF3 via drinking water suppressed the IBD symptoms, such as shortening of colon length, damage to the colon mucosa as observed under the microscope, and spleen enlargement. This result suggests that heat-killed L. lactis BF3 has the potential to treat IBD. BMFH Press 2016-04-19 2016 /pmc/articles/PMC4965518/ /pubmed/27508115 http://dx.doi.org/10.12938/bmfh.2016-007 Text en BMFH Press http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Note
NAKATA, Toru
HIRANO, Shino
YOKOTA, Yasushi
TAKAHASHI, Hajime
KIMURA, Bon
KUDA, Takashi
ETO, Tadashi
KATO, Michiko
Protective effects of heat-killed Lactococcus lactis subsp. lactis BF3, isolated from the intestine of chum salmon, in a murine model of DSS-induced inflammatory bowel disease
title Protective effects of heat-killed Lactococcus lactis subsp. lactis BF3, isolated from the intestine of chum salmon, in a murine model of DSS-induced inflammatory bowel disease
title_full Protective effects of heat-killed Lactococcus lactis subsp. lactis BF3, isolated from the intestine of chum salmon, in a murine model of DSS-induced inflammatory bowel disease
title_fullStr Protective effects of heat-killed Lactococcus lactis subsp. lactis BF3, isolated from the intestine of chum salmon, in a murine model of DSS-induced inflammatory bowel disease
title_full_unstemmed Protective effects of heat-killed Lactococcus lactis subsp. lactis BF3, isolated from the intestine of chum salmon, in a murine model of DSS-induced inflammatory bowel disease
title_short Protective effects of heat-killed Lactococcus lactis subsp. lactis BF3, isolated from the intestine of chum salmon, in a murine model of DSS-induced inflammatory bowel disease
title_sort protective effects of heat-killed lactococcus lactis subsp. lactis bf3, isolated from the intestine of chum salmon, in a murine model of dss-induced inflammatory bowel disease
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965518/
https://www.ncbi.nlm.nih.gov/pubmed/27508115
http://dx.doi.org/10.12938/bmfh.2016-007
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