Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice

Schizophrenia is a chronic psychiatric illness. Disruption of the dopaminergic system has been suggested to be the pathogenic cause of this disease. The effect of Bifidobacterium longum BB536 (BB536) on schizophrenic behavior was investigated in an animal model. Daily administration of BB536 (10(9)...

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Autores principales: ORIKASA, Shuzo, NABESHIMA, Kazumi, IWABUCHI, Noriyuki, XIAO, Jin-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMFH Press 2016
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965519/
https://www.ncbi.nlm.nih.gov/pubmed/27508116
http://dx.doi.org/10.12938/bmfh.2016-004
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author ORIKASA, Shuzo
NABESHIMA, Kazumi
IWABUCHI, Noriyuki
XIAO, Jin-Zhong
author_facet ORIKASA, Shuzo
NABESHIMA, Kazumi
IWABUCHI, Noriyuki
XIAO, Jin-Zhong
author_sort ORIKASA, Shuzo
collection PubMed
description Schizophrenia is a chronic psychiatric illness. Disruption of the dopaminergic system has been suggested to be the pathogenic cause of this disease. The effect of Bifidobacterium longum BB536 (BB536) on schizophrenic behavior was investigated in an animal model. Daily administration of BB536 (10(9) CFU/mouse, p.o. for 2 weeks) was found to reduce rearing behavior augmented by the dopamine receptor agonist apomorphine and to decrease the resting level of plasma corticosterone and the ratio of kynurenine to tryptophan. These results suggest the potential of BB536 for supplemental treatment of the symptoms of schizophrenia.
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spelling pubmed-49655192016-08-09 Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice ORIKASA, Shuzo NABESHIMA, Kazumi IWABUCHI, Noriyuki XIAO, Jin-Zhong Biosci Microbiota Food Health Note Schizophrenia is a chronic psychiatric illness. Disruption of the dopaminergic system has been suggested to be the pathogenic cause of this disease. The effect of Bifidobacterium longum BB536 (BB536) on schizophrenic behavior was investigated in an animal model. Daily administration of BB536 (10(9) CFU/mouse, p.o. for 2 weeks) was found to reduce rearing behavior augmented by the dopamine receptor agonist apomorphine and to decrease the resting level of plasma corticosterone and the ratio of kynurenine to tryptophan. These results suggest the potential of BB536 for supplemental treatment of the symptoms of schizophrenia. BMFH Press 2016-05-11 2016 /pmc/articles/PMC4965519/ /pubmed/27508116 http://dx.doi.org/10.12938/bmfh.2016-004 Text en BMFH Press http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Note
ORIKASA, Shuzo
NABESHIMA, Kazumi
IWABUCHI, Noriyuki
XIAO, Jin-Zhong
Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice
title Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice
title_full Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice
title_fullStr Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice
title_full_unstemmed Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice
title_short Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice
title_sort effect of repeated oral administration of bifidobacterium longum bb536 on apomorphine-induced rearing behavior in mice
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965519/
https://www.ncbi.nlm.nih.gov/pubmed/27508116
http://dx.doi.org/10.12938/bmfh.2016-004
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