Coexistence of Acute Crescent Glomerulonephritis and IgG4-Related Kidney Disease

INTRODUCTION: IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder that may involve almost each organ or system. IgG4-related kidney disease (IgG4-RKD) refers to renal lesions associated with IgG4-RD. The most frequent morphological type of renal lesions is IgG4-related tubulointerstitial...

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Detalles Bibliográficos
Autores principales: Lu, Zeyuan, Yin, Jianyong, Bao, Hongda, Jiao, Qiong, Wu, Huijuan, Wu, Rui, Xue, Qin, Wang, Niansong, Zhang, Zhigang, Wang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965529/
https://www.ncbi.nlm.nih.gov/pubmed/27504450
http://dx.doi.org/10.1159/000448025
Descripción
Sumario:INTRODUCTION: IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder that may involve almost each organ or system. IgG4-related kidney disease (IgG4-RKD) refers to renal lesions associated with IgG4-RD. The most frequent morphological type of renal lesions is IgG4-related tubulointerstitial nephritis (IgG4-TIN) which is associated with increased IgG4-positive plasma cell infiltration and interstitial fibrosis. CASE REPORT: Herein, we present a rare case with coexisting IgG4-RKD and acute crescent glomerulonephritis with concomitant severe tubulointerstitial lesions instead of classic IgG4-TIN. CONCLUSION: IgG4-RKD and acute crescent glomerulonephritis can occur in the same patient. This case may give us a clearer viewpoint of the disease.

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