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Risk Factors for Relapse of Human Brucellosis

BACKGROUND & PROPOSE: Brucellosis is serious disease around the world, especially in underdeveloped countries. Relapse is major problem in therapy of brucellosis. This study aimed to evaluate risk factors of relapse after treatment in patients. METHODS: It is a descriptive-analytic study from 19...

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Autores principales: Hasanjani Roushan, Mohammad Reza, Moulana, Zahra, Afshar, Zeinab Mohseni, Ebrahimpour, Soheil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Canadian Center of Science and Education 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965643/
https://www.ncbi.nlm.nih.gov/pubmed/26925907
http://dx.doi.org/10.5539/gjhs.v8n7p77
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author Hasanjani Roushan, Mohammad Reza
Moulana, Zahra
Afshar, Zeinab Mohseni
Ebrahimpour, Soheil
author_facet Hasanjani Roushan, Mohammad Reza
Moulana, Zahra
Afshar, Zeinab Mohseni
Ebrahimpour, Soheil
author_sort Hasanjani Roushan, Mohammad Reza
collection PubMed
description BACKGROUND & PROPOSE: Brucellosis is serious disease around the world, especially in underdeveloped countries. Relapse is major problem in therapy of brucellosis. This study aimed to evaluate risk factors of relapse after treatment in patients. METHODS: It is a descriptive-analytic study from 1990 to 2014, in Ayatolla Rohani hospital in Babol, Iran. We studied 980 patients with brucellosis. The studied community included patients infected with brucellosis and the required information was gathered based on their hospital files. The base for recognizing Malta fever were clinical symptoms and Para-clinical sign congruent with infection like as, titer SAT>1:320 and 2-ME>1:160. Patients with relapse and patients without relapse were placed separately in two groups. The data were statistically compared with Spss 16, by Chi-square and Cox–regression tests. RESULTS: Based on this study, treatment regimen is a preventive factor (P=0.000). Moreover, Based on some statistical methods, regimens no. 3 and 4 were introduce preventive factors (P=0.001) and (P=0.004). It should also be noted that findings the same statistical model, factors like gender, age, residence, professional contacts, complications and delay in treatment were also analyzed but none of them are considered as preventive factors. CONCLUSION: Based our finding, we suggest aminoglycosides (gentamicin or streptomycin with doxycycline) are associated with lower rate of relapse in brucellosis.
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spelling pubmed-49656432016-08-02 Risk Factors for Relapse of Human Brucellosis Hasanjani Roushan, Mohammad Reza Moulana, Zahra Afshar, Zeinab Mohseni Ebrahimpour, Soheil Glob J Health Sci Article BACKGROUND & PROPOSE: Brucellosis is serious disease around the world, especially in underdeveloped countries. Relapse is major problem in therapy of brucellosis. This study aimed to evaluate risk factors of relapse after treatment in patients. METHODS: It is a descriptive-analytic study from 1990 to 2014, in Ayatolla Rohani hospital in Babol, Iran. We studied 980 patients with brucellosis. The studied community included patients infected with brucellosis and the required information was gathered based on their hospital files. The base for recognizing Malta fever were clinical symptoms and Para-clinical sign congruent with infection like as, titer SAT>1:320 and 2-ME>1:160. Patients with relapse and patients without relapse were placed separately in two groups. The data were statistically compared with Spss 16, by Chi-square and Cox–regression tests. RESULTS: Based on this study, treatment regimen is a preventive factor (P=0.000). Moreover, Based on some statistical methods, regimens no. 3 and 4 were introduce preventive factors (P=0.001) and (P=0.004). It should also be noted that findings the same statistical model, factors like gender, age, residence, professional contacts, complications and delay in treatment were also analyzed but none of them are considered as preventive factors. CONCLUSION: Based our finding, we suggest aminoglycosides (gentamicin or streptomycin with doxycycline) are associated with lower rate of relapse in brucellosis. Canadian Center of Science and Education 2016-07 2015-11-03 /pmc/articles/PMC4965643/ /pubmed/26925907 http://dx.doi.org/10.5539/gjhs.v8n7p77 Text en Copyright: © Canadian Center of Science and Education http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Hasanjani Roushan, Mohammad Reza
Moulana, Zahra
Afshar, Zeinab Mohseni
Ebrahimpour, Soheil
Risk Factors for Relapse of Human Brucellosis
title Risk Factors for Relapse of Human Brucellosis
title_full Risk Factors for Relapse of Human Brucellosis
title_fullStr Risk Factors for Relapse of Human Brucellosis
title_full_unstemmed Risk Factors for Relapse of Human Brucellosis
title_short Risk Factors for Relapse of Human Brucellosis
title_sort risk factors for relapse of human brucellosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965643/
https://www.ncbi.nlm.nih.gov/pubmed/26925907
http://dx.doi.org/10.5539/gjhs.v8n7p77
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