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Preterm Birth Prevention: Effects of Vaginal Progesterone Administration on Blood Flow Impedance in Uterine-Fetal Circulation by Doppler Sonography
OBJECTIVE: The present study aimed to evaluate the effect of vaginal progesterone administration on maternal and fetal circulation to prevent preterm birth. METHODS: The present prospective study was conducted on 35 women with singleton pregnancy at 18–33 weeks of gestation, who presented with at le...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Canadian Center of Science and Education
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965675/ https://www.ncbi.nlm.nih.gov/pubmed/26925899 http://dx.doi.org/10.5539/gjhs.v8n7p172 |
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author | Vafaei, Homeira Zamanpour, Tarlan Shahraki, Hadi Raeisi |
author_facet | Vafaei, Homeira Zamanpour, Tarlan Shahraki, Hadi Raeisi |
author_sort | Vafaei, Homeira |
collection | PubMed |
description | OBJECTIVE: The present study aimed to evaluate the effect of vaginal progesterone administration on maternal and fetal circulation to prevent preterm birth. METHODS: The present prospective study was conducted on 35 women with singleton pregnancy at 18–33 weeks of gestation, who presented with at least one episode of preterm labor or asymptomatic short cervix, or past medical history of preterm birth. Doppler flow and Pulsatility Index (PI) assessment of the umbilical artery, fetal middle cerebral artery, uterine arteries, and ductusvenosus were performed before and 72 h after vaginal progesterone administration. RESULTS: Results showed a significant reduction in the PI of the uterine artery following progesterone administration. Nevertheless, no significant changes were observed in the PI of other vessels. No significant difference was found in Doppler flow parameters in any of the examined vessels before or after progesterone treatment in women with Preterm Labor Pain (PLP). Yet, a statistically significant association was observed between short cervix complication in the current pregnancy and medical history of PLP in the previous pregnancy. CONCLUSION: Treatment with vaginal progesterone reduced the PI in the uterine arteries in the second and third trimesters of pregnancy. Thus, this medication may have useful vasodilatory effects on uterine-fetal vessels. |
format | Online Article Text |
id | pubmed-4965675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Canadian Center of Science and Education |
record_format | MEDLINE/PubMed |
spelling | pubmed-49656752016-08-02 Preterm Birth Prevention: Effects of Vaginal Progesterone Administration on Blood Flow Impedance in Uterine-Fetal Circulation by Doppler Sonography Vafaei, Homeira Zamanpour, Tarlan Shahraki, Hadi Raeisi Glob J Health Sci Article OBJECTIVE: The present study aimed to evaluate the effect of vaginal progesterone administration on maternal and fetal circulation to prevent preterm birth. METHODS: The present prospective study was conducted on 35 women with singleton pregnancy at 18–33 weeks of gestation, who presented with at least one episode of preterm labor or asymptomatic short cervix, or past medical history of preterm birth. Doppler flow and Pulsatility Index (PI) assessment of the umbilical artery, fetal middle cerebral artery, uterine arteries, and ductusvenosus were performed before and 72 h after vaginal progesterone administration. RESULTS: Results showed a significant reduction in the PI of the uterine artery following progesterone administration. Nevertheless, no significant changes were observed in the PI of other vessels. No significant difference was found in Doppler flow parameters in any of the examined vessels before or after progesterone treatment in women with Preterm Labor Pain (PLP). Yet, a statistically significant association was observed between short cervix complication in the current pregnancy and medical history of PLP in the previous pregnancy. CONCLUSION: Treatment with vaginal progesterone reduced the PI in the uterine arteries in the second and third trimesters of pregnancy. Thus, this medication may have useful vasodilatory effects on uterine-fetal vessels. Canadian Center of Science and Education 2016-07 2015-11-18 /pmc/articles/PMC4965675/ /pubmed/26925899 http://dx.doi.org/10.5539/gjhs.v8n7p172 Text en Copyright: © Canadian Center of Science and Education http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Vafaei, Homeira Zamanpour, Tarlan Shahraki, Hadi Raeisi Preterm Birth Prevention: Effects of Vaginal Progesterone Administration on Blood Flow Impedance in Uterine-Fetal Circulation by Doppler Sonography |
title | Preterm Birth Prevention: Effects of Vaginal Progesterone Administration on Blood Flow Impedance in Uterine-Fetal Circulation by Doppler Sonography |
title_full | Preterm Birth Prevention: Effects of Vaginal Progesterone Administration on Blood Flow Impedance in Uterine-Fetal Circulation by Doppler Sonography |
title_fullStr | Preterm Birth Prevention: Effects of Vaginal Progesterone Administration on Blood Flow Impedance in Uterine-Fetal Circulation by Doppler Sonography |
title_full_unstemmed | Preterm Birth Prevention: Effects of Vaginal Progesterone Administration on Blood Flow Impedance in Uterine-Fetal Circulation by Doppler Sonography |
title_short | Preterm Birth Prevention: Effects of Vaginal Progesterone Administration on Blood Flow Impedance in Uterine-Fetal Circulation by Doppler Sonography |
title_sort | preterm birth prevention: effects of vaginal progesterone administration on blood flow impedance in uterine-fetal circulation by doppler sonography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965675/ https://www.ncbi.nlm.nih.gov/pubmed/26925899 http://dx.doi.org/10.5539/gjhs.v8n7p172 |
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