Cargando…

Novel combination of sorafenib and biochanin-A synergistically enhances the anti-proliferative and pro-apoptotic effects on hepatocellular carcinoma cells

Sorafenib (SOR) is the first-line treatment for hepatocellular carcinoma (HCC). However, its use is hindered by the recently expressed safety concerns. One approach for reducing SOR toxicity is to use lower doses in combination with other less toxic agents. Biochanin-A (Bio-A), a promising isoflavon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Youssef , Mohieldin M., Tolba, Mai F., Badawy, Noha N., Liu, Andrew W., El-Ahwany, Eman, Khalifa, Amani E., Zada, Suher, Abdel-Naim, Ashraf B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965826/ https://www.ncbi.nlm.nih.gov/pubmed/27470322 http://dx.doi.org/10.1038/srep30717

Ejemplares similares

Multimechanistic Antifibrotic Effect of Biochanin A in Rats: Implications of Proinflammatory and Profibrogenic Mediators
por: Breikaa, Randa M., et al.
Publicado: (2013)

Induction of Anti-Proliferative and Apoptotic Effects of Sorafenib Using miR-27a Inhibitor in Hepatocellular Carcinoma Cell Lines
por: Abdel Wahab, Abdel Hady A, et al.
Publicado: (2021)

Protective Role of Purified Cysteine Proteinases against Fasciola gigantica Infection in Experimental Animals
por: EL-Ahwany, Eman, et al.
Publicado: (2012)

Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells
por: Cervello, Melchiorre, et al.
Publicado: (2013)

T Regulatory Cell Responses to Immunization with a Soluble Egg Antigen in Schistosoma mansoni-Infected Mice
por: El-Ahwany, Eman, et al.
Publicado: (2012)

The Role of MicroRNAs in Response to Interferon Treatment of Chronic Hepatitis C patients
por: El-Ahwany, Eman, et al.
Publicado: (2016)

Microbial Glycosylation of Daidzein, Genistein and Biochanin A: Two New Glucosides of Biochanin A
por: Sordon, Sandra, et al.
Publicado: (2017)

OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53
por: Omar, Hany A., et al.
Publicado: (2016)

Circulating miRNAs as Predictor Markers for Activation of Hepatic Stellate Cells and Progression of HCV-Induced Liver Fibrosis
por: El-Ahwany, Eman, et al.
Publicado: (2016)

MicroRNA-122a as a non-invasive biomarker for HCV genotype 4-related hepatocellular carcinoma in Egyptian patients
por: El-Ahwany, Eman G. E., et al.
Publicado: (2019)

Self-Nanoemulsifying Drug Delivery System of 2-Methoxyestradiol Exhibits Enhanced Anti-Proliferative and Pro-Apoptotic Activities in MCF-7 Breast Cancer Cells
por: Al-Qahtani, Salwa D., et al.
Publicado: (2022)

EFFECT OF BIOCHANIN – A AGAINST FILARIAL VECTOR
por: Nagarajan, N.S., et al.
Publicado: (1998)

Perspectives Regarding the Role of Biochanin A in Humans
por: Yu, Chen, et al.
Publicado: (2019)

Biochanin A Gastroprotective Effects in Ethanol-Induced Gastric Mucosal Ulceration in Rats
por: Hajrezaie, Maryam, et al.
Publicado: (2015)

In Silico Design and Experimental Validation of siRNAs Targeting Conserved Regions of Multiple Hepatitis C Virus Genotypes
por: ElHefnawi, Mahmoud, et al.
Publicado: (2016)

Biochanin-A attenuates neuropathic pain in diabetic rats
por: Chundi, Venkateswarlu, et al.
Publicado: (2016)

Therapeutic Potential of Biochanin A in Herpes Simplex Keratitis
por: Zhou, Nan, et al.
Publicado: (2023)

Correction: Al-Qahtani et al. Self-Nanoemulsifying Drug Delivery System of 2-Methoxyestradiol Exhibits Enhanced Anti-Proliferative and Pro-Apoptotic Activities in MCF-7 Breast Cancer Cells. Life 2022, 12, 1369
por: Al-Qahtani, Salwa D., et al.
Publicado: (2023)

Biochanin A Ameliorates Arsenic-Induced Hepato- and Hematotoxicity in Rats
por: Jalaludeen, Abdulkadhar Mohamed, et al.
Publicado: (2016)

Chemical and Biological Properties of Biochanin A and Its Pharmaceutical Applications
por: Feng, Zhen-Jie, et al.
Publicado: (2023)

The Antioxidant, Anti-Apoptotic, and Proliferative Potency of Argan Oil against Betamethasone-Induced Oxidative Renal Damage in Rats
por: Orabi, Sahar Hassan, et al.
Publicado: (2020)

Heparin-Tagged PLA-PEG Copolymer-Encapsulated Biochanin A-Loaded (Mg/Al) LDH Nanoparticles Recommended for Non-Thrombogenic and Anti-Proliferative Stent Coating
por: Adepu, Shivakalyani, et al.
Publicado: (2021)

The Synergistic Effects of Curcumin and Chemotherapeutic Drugs in Inhibiting Metastatic, Invasive and Proliferative Pathways
por: Younes, Maria, et al.
Publicado: (2022)

Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies
por: Wu, Ding-Qian, et al.
Publicado: (2014)

Mechanisms of phytoestrogen biochanin A-induced vasorelaxation in renovascular hypertensive rats
por: Choi, Seok, et al.
Publicado: (2014)

Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells
por: Li, Yan, et al.
Publicado: (2018)

Electrospun Poly(lactide) Fibers as Carriers for Controlled Release of Biochanin A
por: Gajić, Ivana, et al.
Publicado: (2022)

Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response
por: Yu, Xiao-Hua, et al.
Publicado: (2020)

Activity of isoflavone biochanin A in chronic experimental toxoplasmosis: impact on inflammation
por: Aboukamar, Wafaa A., et al.
Publicado: (2022)

Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1
por: Li, Jianjun, et al.
Publicado: (2022)

Liver Protective Effects of Renin-Angiotensin System Inhibition Have No Survival Benefits in Hepatocellular Carcinoma Induced By Repetitive Administration of Diethylnitrosamine in Mice
por: Saber, Sameh, et al.
Publicado: (2018)

Biochanin A Improves Memory Decline and Brain Pathology in Cuprizone-Induced Mouse Model of Multiple Sclerosis
por: Aldhahri, Rahaf Saeed, et al.
Publicado: (2022)

Apoptotic Effects of Genistein, Biochanin-A and Apigenin on LNCaP and PC-3 Cells by p21 through Transcriptional Inhibition of Polo-like Kinase-1
por: Seo, Young Jin, et al.
Publicado: (2011)

The Proliferative and Apoptotic Landscape of Basal-like Breast Cancer
por: Alexandrou, Sarah, et al.
Publicado: (2019)

Genistein Improves 3-NPA-Induced Memory Impairment in Ovariectomized Rats: Impact of Its Antioxidant, Anti-Inflammatory and Acetylcholinesterase Modulatory Properties
por: Menze, Esther T., et al.
Publicado: (2015)

Combination of ERK2 inhibitor VX-11e and voreloxin synergistically enhances anti-proliferative and pro-apoptotic effects in leukemia cells
por: Jasek-Gajda, Ewa, et al.
Publicado: (2019)

Effect of Biochanin A on Serum Visfatin Level of Streptozocin-Induced Diabetic Rats
por: Azizi, Reza, et al.
Publicado: (2014)

Biochanin A extirpates the epithelial-mesenchymal transition in a human lung cancer
por: Wang, Yan, et al.
Publicado: (2018)

In Vitro Synergy of Biochanin A and Ciprofloxacin against Clinical Isolates of Staphylococcus aureus
por: Liu, Guoxing, et al.
Publicado: (2011)

Network Pharmacology Integrated Molecular Docking Reveals the Antiosteosarcoma Mechanism of Biochanin A
por: Luo, Qing, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_mbkcbfp53aps0sbbs23lka4p96