Dapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management

Dapsone (4,4’- diaminodiphenylsulfone) is the parent compound of the sulfones, and it has potent antiparasitic, anti-inflammatory, and immunomodulatory effects. It is used in the treatment of leprosy, dermatitis herpetiformis, and prophylactically to prevent Pneumocystis pneumonia and toxoplasmosis...

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Autores principales: Sawlani, Kamal Kumar, Chaudhary, Shyam Chand, Singh, Jitendra, Raja, Deep Chandh, Mishra, Sanjay, Goel, Madhu Mati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966243/
https://www.ncbi.nlm.nih.gov/pubmed/27512715
http://dx.doi.org/10.4103/2279-042X.185743
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author Sawlani, Kamal Kumar
Chaudhary, Shyam Chand
Singh, Jitendra
Raja, Deep Chandh
Mishra, Sanjay
Goel, Madhu Mati
author_facet Sawlani, Kamal Kumar
Chaudhary, Shyam Chand
Singh, Jitendra
Raja, Deep Chandh
Mishra, Sanjay
Goel, Madhu Mati
author_sort Sawlani, Kamal Kumar
collection PubMed
description Dapsone (4,4’- diaminodiphenylsulfone) is the parent compound of the sulfones, and it has potent antiparasitic, anti-inflammatory, and immunomodulatory effects. It is used in the treatment of leprosy, dermatitis herpetiformis, and prophylactically to prevent Pneumocystis pneumonia and toxoplasmosis in patients unable to tolerate trimethoprim with sulfamethoxazole. We hereby report a case of dapsone toxicity who developed pure red cell aplasia and cholestatic jaundice in a suspected case of dermatitis herpetiformis. Patient had an excellent response to corticosteroids after withdrawal of dapsone.
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spelling pubmed-49662432016-08-10 Dapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management Sawlani, Kamal Kumar Chaudhary, Shyam Chand Singh, Jitendra Raja, Deep Chandh Mishra, Sanjay Goel, Madhu Mati J Res Pharm Pract Case Report Dapsone (4,4’- diaminodiphenylsulfone) is the parent compound of the sulfones, and it has potent antiparasitic, anti-inflammatory, and immunomodulatory effects. It is used in the treatment of leprosy, dermatitis herpetiformis, and prophylactically to prevent Pneumocystis pneumonia and toxoplasmosis in patients unable to tolerate trimethoprim with sulfamethoxazole. We hereby report a case of dapsone toxicity who developed pure red cell aplasia and cholestatic jaundice in a suspected case of dermatitis herpetiformis. Patient had an excellent response to corticosteroids after withdrawal of dapsone. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4966243/ /pubmed/27512715 http://dx.doi.org/10.4103/2279-042X.185743 Text en Copyright: © 2016 Journal of Research in Pharmacy Practice http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Sawlani, Kamal Kumar
Chaudhary, Shyam Chand
Singh, Jitendra
Raja, Deep Chandh
Mishra, Sanjay
Goel, Madhu Mati
Dapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management
title Dapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management
title_full Dapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management
title_fullStr Dapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management
title_full_unstemmed Dapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management
title_short Dapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management
title_sort dapsone-induced pure red cell aplasia and cholestatic jaundice: a new experience for diagnosis and management
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966243/
https://www.ncbi.nlm.nih.gov/pubmed/27512715
http://dx.doi.org/10.4103/2279-042X.185743
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