Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa

We report here the complete genome sequence of a lineage 2 West Nile virus (WNV) strain that resulted in fatal neurological disease in a horse in South Africa. Several recent reports exist of neurological disease associated with lineage 2 WNV in humans and horses in South Africa and Europe; however,...

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Autores principales: Mentoor, Juliet L. D., Lubisi, Alison B., Gerdes, Truuska, Human, Stacey, Williams, June H., Venter, Marietjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Viruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966467/
https://www.ncbi.nlm.nih.gov/pubmed/27469963
http://dx.doi.org/10.1128/genomeA.00740-16
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author Mentoor, Juliet L. D.
Lubisi, Alison B.
Gerdes, Truuska
Human, Stacey
Williams, June H.
Venter, Marietjie
author_facet Mentoor, Juliet L. D.
Lubisi, Alison B.
Gerdes, Truuska
Human, Stacey
Williams, June H.
Venter, Marietjie
author_sort Mentoor, Juliet L. D.
collection PubMed
description We report here the complete genome sequence of a lineage 2 West Nile virus (WNV) strain that resulted in fatal neurological disease in a horse in South Africa. Several recent reports exist of neurological disease associated with lineage 2 WNV in humans and horses in South Africa and Europe; however, there are a lack of sequencing data from recent fatal cases in Southern Africa, where these strains likely originate. A better understanding of the genetic composition of highly neuroinvasive lineage 2 strains may facilitate the identification of putative genetic factors associated with increased virulence.
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spelling pubmed-49664672016-08-08 Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa Mentoor, Juliet L. D. Lubisi, Alison B. Gerdes, Truuska Human, Stacey Williams, June H. Venter, Marietjie Genome Announc Viruses We report here the complete genome sequence of a lineage 2 West Nile virus (WNV) strain that resulted in fatal neurological disease in a horse in South Africa. Several recent reports exist of neurological disease associated with lineage 2 WNV in humans and horses in South Africa and Europe; however, there are a lack of sequencing data from recent fatal cases in Southern Africa, where these strains likely originate. A better understanding of the genetic composition of highly neuroinvasive lineage 2 strains may facilitate the identification of putative genetic factors associated with increased virulence. American Society for Microbiology 2016-07-28 /pmc/articles/PMC4966467/ /pubmed/27469963 http://dx.doi.org/10.1128/genomeA.00740-16 Text en Copyright © 2016 Mentoor et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Viruses
Mentoor, Juliet L. D.
Lubisi, Alison B.
Gerdes, Truuska
Human, Stacey
Williams, June H.
Venter, Marietjie
Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa
title Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa
title_full Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa
title_fullStr Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa
title_full_unstemmed Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa
title_short Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa
title_sort full-genome sequence of a neuroinvasive west nile virus lineage 2 strain from a fatal horse infection in south africa
topic Viruses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966467/
https://www.ncbi.nlm.nih.gov/pubmed/27469963
http://dx.doi.org/10.1128/genomeA.00740-16
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