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A rapid on-line method for mass spectrometric confirmation of a cysteine-conjugated antibody-drug-conjugate structure using multidimensional chromatography

Cysteine-conjugated antibody-drug conjugates (ADCs) are manufactured using controlled partial reduction and conjugation chemistry with drug payloads that typically occur in intervals of 0, 2, 4, 6, and 8. Control of heterogeneity is of particular importance to the quality of ADC product because drug...

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Detalles Bibliográficos
Autores principales:	Birdsall, Robert E, Shion, Henry, Kotch, Frank W, Xu, April, Porter, Thomas J, Chen, Weibin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966495/ https://www.ncbi.nlm.nih.gov/pubmed/26305867 http://dx.doi.org/10.1080/19420862.2015.1083665

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