The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration

BACKGROUND: The most abundant cells in the extensive desmoplastic stroma of pancreatic adenocarcinomas are the pancreatic stellate cells, which interact with the carcinoma cells and strongly influence the progression of the cancer. Tumor stroma interactions induced by IL-1α/IL-1R1 signaling have bee...

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Detalles Bibliográficos
Autores principales: Tjomsland, Vegard, Sandnes, Dagny, Pomianowska, Ewa, Cizmovic, Smiljana Torbica, Aasrum, Monica, Brusevold, Ingvild Johnsen, Christoffersen, Thoralf, Gladhaug, Ivar P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966589/
https://www.ncbi.nlm.nih.gov/pubmed/27473228
http://dx.doi.org/10.1186/s13046-016-0400-5

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