Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry

High-molecular weight aggregates such as antibody dimers and other side products derived from incorrect light or heavy chain association typically represent critical product-related impurities for bispecific antibody formats. In this study, an approach employing ultra-pressure liquid chromatography...

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Detalles Bibliográficos
Autores principales: Haberger, Markus, Leiss, Michael, Heidenreich, Anna-Katharina, Pester, Oxana, Hafenmair, Georg, Hook, Michaela, Bonnington, Lea, Wegele, Harald, Haindl, Markus, Reusch, Dietmar, Bulau, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966600/
https://www.ncbi.nlm.nih.gov/pubmed/26655595
http://dx.doi.org/10.1080/19420862.2015.1122150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966600/
https://www.ncbi.nlm.nih.gov/pubmed/26655595
http://dx.doi.org/10.1080/19420862.2015.1122150

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