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Evaluation of a glycoengineered monoclonal antibody via LC-MS analysis in combination with multiple enzymatic digestion

Glycosylation affects the efficacy, safety and pharmacokinetics/pharmacodynamics properties of therapeutic monoclonal antibodies (mAbs), and glycoengineering is now being used to produce mAbs with improved efficacy. In this work, a glycoengineered version of rituximab was produced by chemoenzymatic...

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Detalles Bibliográficos
Autores principales:	Liu, Renpeng, Giddens, John, McClung, Colleen M., Magnelli, Paula E., Wang, Lai-Xi, Guthrie, Ellen P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966608/ https://www.ncbi.nlm.nih.gov/pubmed/26514686 http://dx.doi.org/10.1080/19420862.2015.1113361

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