A sensitive multidimensional method for the detection, characterization, and quantification of trace free drug species in antibody-drug conjugate samples using mass spectral detection

Conjugation processes and stability studies associated with the production and shelf life of antibody-drug conjugates (ADCs) can result in free (non-conjugated) drug species. These free drug species can increase the risk to patients and reduce the efficacy of the ADC. Despite stringent purification...

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Detalles Bibliográficos
Autores principales: Birdsall, Robert E., McCarthy, Sean M., Janin-Bussat, Marie Claire, Perez, Michel, Haeuw, Jean-François, Chen, Weibin, Beck, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966627/
https://www.ncbi.nlm.nih.gov/pubmed/26651262
http://dx.doi.org/10.1080/19420862.2015.1116659

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