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Anti-tumoral, anti-angiogenic and anti-metastatic efficacy of a tetravalent bispecific antibody (TAvi6) targeting VEGF-A and angiopoietin-2

Vascular endothelial growth factor (VEGF)-A blockade has been validated clinically as a treatment for human cancers. Angiopoietin-2 (Ang-2) is a key regulator of blood vessel remodeling and maturation. In tumors, Ang-2 is up-regulated and an unfavorable prognostic factor. Recent data demonstrated th...

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Detalles Bibliográficos
Autores principales:	Scheuer, Werner, Thomas, Markus, Hanke, Petra, Sam, Johannes, Osl, Franz, Weininger, Diana, Baehner, Monika, Seeber, Stefan, Kettenberger, Hubert, Schanzer, Jürgen, Brinkmann, Ulrich, Weidner, K. Michael, Regula, Jörg, Klein, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966847/ https://www.ncbi.nlm.nih.gov/pubmed/26864324 http://dx.doi.org/10.1080/19420862.2016.1147640

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