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Predialysis nephrology care and dialysis-related health outcomes among older adults initiating dialysis

BACKGROUND: Predialysis nephrology care is associated with lower mortality and rates of hospitalization following chronic dialysis initiation. Whether more frequent predialysis nephrology care is associated with other favorable outcomes for older adults is not known. METHODS: Retrospective cohort st...

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Autores principales: Fischer, Michael J., Stroupe, Kevin T., Kaufman, James S., O’Hare, Ann M., Browning, Margaret M., Sohn, Min-Woong, Huo, Zhiping, Hynes, Denise M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966864/
https://www.ncbi.nlm.nih.gov/pubmed/27473684
http://dx.doi.org/10.1186/s12882-016-0324-5
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author Fischer, Michael J.
Stroupe, Kevin T.
Kaufman, James S.
O’Hare, Ann M.
Browning, Margaret M.
Sohn, Min-Woong
Huo, Zhiping
Hynes, Denise M.
author_facet Fischer, Michael J.
Stroupe, Kevin T.
Kaufman, James S.
O’Hare, Ann M.
Browning, Margaret M.
Sohn, Min-Woong
Huo, Zhiping
Hynes, Denise M.
author_sort Fischer, Michael J.
collection PubMed
description BACKGROUND: Predialysis nephrology care is associated with lower mortality and rates of hospitalization following chronic dialysis initiation. Whether more frequent predialysis nephrology care is associated with other favorable outcomes for older adults is not known. METHODS: Retrospective cohort study of patients ≥66 years who initiated chronic dialysis in 2000–2001 and were eligible for VA and/or Medicare-covered services. Nephrology visits in VA and/or Medicare during the 12-month predialysis period were identified and classified by low intensity (<3 visits), moderate intensity (3–6 visits), and high intensity (>6 visits). Outcome measures included very low estimated glomerular filtration rate, severe anemia, use of peritoneal dialysis, and receipt of permanent vascular access at dialysis initiation and death and kidney transplantation within two years of initiation. Generalized linear models with propensity score weighting were used to examine the association between nephrology care and outcomes. RESULTS: Among 58,014 patients, 46 % had none, 22 % had low, 13 % had moderate, and 19 % had high intensity predialysis nephrology care. Patients with a greater intensity of predialysis nephrology care had more favorable outcomes (all p < 0.001). In adjusted models, patients with high intensity predialysis nephrology care were less likely to have severe anemia (RR = 0.70, 99 % CI: 0.65–0.74) and more likely to have permanent vascular access (RR = 3.60, 99 % CI: 3.42–3.79) at dialysis initiation, and less likely to die within two years of dialysis initiation (RR = 0.80, 99 % CI: 0.77–0.82). CONCLUSION: In a large cohort of older adults treated with chronic dialysis, greater intensity of predialysis nephrology care was associated with more favorable outcomes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12882-016-0324-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-49668642016-07-30 Predialysis nephrology care and dialysis-related health outcomes among older adults initiating dialysis Fischer, Michael J. Stroupe, Kevin T. Kaufman, James S. O’Hare, Ann M. Browning, Margaret M. Sohn, Min-Woong Huo, Zhiping Hynes, Denise M. BMC Nephrol Research Article BACKGROUND: Predialysis nephrology care is associated with lower mortality and rates of hospitalization following chronic dialysis initiation. Whether more frequent predialysis nephrology care is associated with other favorable outcomes for older adults is not known. METHODS: Retrospective cohort study of patients ≥66 years who initiated chronic dialysis in 2000–2001 and were eligible for VA and/or Medicare-covered services. Nephrology visits in VA and/or Medicare during the 12-month predialysis period were identified and classified by low intensity (<3 visits), moderate intensity (3–6 visits), and high intensity (>6 visits). Outcome measures included very low estimated glomerular filtration rate, severe anemia, use of peritoneal dialysis, and receipt of permanent vascular access at dialysis initiation and death and kidney transplantation within two years of initiation. Generalized linear models with propensity score weighting were used to examine the association between nephrology care and outcomes. RESULTS: Among 58,014 patients, 46 % had none, 22 % had low, 13 % had moderate, and 19 % had high intensity predialysis nephrology care. Patients with a greater intensity of predialysis nephrology care had more favorable outcomes (all p < 0.001). In adjusted models, patients with high intensity predialysis nephrology care were less likely to have severe anemia (RR = 0.70, 99 % CI: 0.65–0.74) and more likely to have permanent vascular access (RR = 3.60, 99 % CI: 3.42–3.79) at dialysis initiation, and less likely to die within two years of dialysis initiation (RR = 0.80, 99 % CI: 0.77–0.82). CONCLUSION: In a large cohort of older adults treated with chronic dialysis, greater intensity of predialysis nephrology care was associated with more favorable outcomes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12882-016-0324-5) contains supplementary material, which is available to authorized users. BioMed Central 2016-07-29 /pmc/articles/PMC4966864/ /pubmed/27473684 http://dx.doi.org/10.1186/s12882-016-0324-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Fischer, Michael J.
Stroupe, Kevin T.
Kaufman, James S.
O’Hare, Ann M.
Browning, Margaret M.
Sohn, Min-Woong
Huo, Zhiping
Hynes, Denise M.
Predialysis nephrology care and dialysis-related health outcomes among older adults initiating dialysis
title Predialysis nephrology care and dialysis-related health outcomes among older adults initiating dialysis
title_full Predialysis nephrology care and dialysis-related health outcomes among older adults initiating dialysis
title_fullStr Predialysis nephrology care and dialysis-related health outcomes among older adults initiating dialysis
title_full_unstemmed Predialysis nephrology care and dialysis-related health outcomes among older adults initiating dialysis
title_short Predialysis nephrology care and dialysis-related health outcomes among older adults initiating dialysis
title_sort predialysis nephrology care and dialysis-related health outcomes among older adults initiating dialysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966864/
https://www.ncbi.nlm.nih.gov/pubmed/27473684
http://dx.doi.org/10.1186/s12882-016-0324-5
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