A Spontaneous Missense Mutation in Branched Chain Keto Acid Dehydrogenase Kinase in the Rat Affects Both the Central and Peripheral Nervous Systems

A novel mutation, causing a phenotype we named frogleg because its most obvious characteristic is a severe splaying of the hind limbs, arose spontaneously in a colony of Sprague-Dawley rats. Frogleg is a complex phenotype that includes abnormalities in hind limb function, reduced brain weight with d...

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Detalles Bibliográficos
Autores principales: Zigler, J. Samuel, Hodgkinson, Colin A., Wright, Megan, Klise, Andrew, Sundin, Olof, Broman, Karl W., Hejtmancik, Fielding, Huang, Hao, Patek, Bonnie, Sergeev, Yuri, Hose, Stacey, Brayton, Cory, Xaiodong, Jiao, Vasquez, David, Maragakis, Nicholas, Mori, Susumu, Goldman, David, Hoke, Ahmet, Sinha, Debasish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966912/
https://www.ncbi.nlm.nih.gov/pubmed/27472223
http://dx.doi.org/10.1371/journal.pone.0160447

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