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Evaluation of pharmacological activity of Hibiscus tiliaceus

Hibiscus tiliaceus, locally known as Bhola was examined for phytochemical properties and its cytotoxic, antibacterial, analgesic and neuropharmacological activities using the ethanol extract of leaf and bark. The phytochemical analysis of the leaf extract indicated the presence of tannins, whereas b...

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Autores principales: Abdul-Awal, S. M., Nazmir, Sonia, Nasrin, Sonia, Nurunnabi, Tauhidur Rahman, Uddin, Shaikh Jamal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967069/
https://www.ncbi.nlm.nih.gov/pubmed/27516947
http://dx.doi.org/10.1186/s40064-016-2891-0
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author Abdul-Awal, S. M.
Nazmir, Sonia
Nasrin, Sonia
Nurunnabi, Tauhidur Rahman
Uddin, Shaikh Jamal
author_facet Abdul-Awal, S. M.
Nazmir, Sonia
Nasrin, Sonia
Nurunnabi, Tauhidur Rahman
Uddin, Shaikh Jamal
author_sort Abdul-Awal, S. M.
collection PubMed
description Hibiscus tiliaceus, locally known as Bhola was examined for phytochemical properties and its cytotoxic, antibacterial, analgesic and neuropharmacological activities using the ethanol extract of leaf and bark. The phytochemical analysis of the leaf extract indicated the presence of tannins, whereas bark extract indicated the presence of alkaloid, reducing sugar and tannins. A preliminary cytotoxicity of these extracts was determined by a simple and low cost assay using brine shrimp lethality. The leaf extract of the plant exhibited moderate cytotoxic effect (LC(50): 20 µg/ml, LC(90): 40 µg/ml) whereas the bark extract exhibited low cytotoxic effect (LC(50): 50 µg/ml). In the analgesic test, the leaf extract showed comparatively high analgesic action than bark extract. There was no activity found in the leaf extract against the test bacterial strains, however bark extract exhibited a very little inhibitory effect on Staphylococcus aureus and Staphylococcus epidermidis. In the neuropharmacological test, the leaf and bark extract produced a decrease in both the time of onset of sleeping and the total sleeping time. The present study showed evidence that both leaf and bark extract of H. tiliaceus contain medicinally important bioactive compounds, thereby used as traditional medicine.
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spelling pubmed-49670692016-08-11 Evaluation of pharmacological activity of Hibiscus tiliaceus Abdul-Awal, S. M. Nazmir, Sonia Nasrin, Sonia Nurunnabi, Tauhidur Rahman Uddin, Shaikh Jamal Springerplus Research Hibiscus tiliaceus, locally known as Bhola was examined for phytochemical properties and its cytotoxic, antibacterial, analgesic and neuropharmacological activities using the ethanol extract of leaf and bark. The phytochemical analysis of the leaf extract indicated the presence of tannins, whereas bark extract indicated the presence of alkaloid, reducing sugar and tannins. A preliminary cytotoxicity of these extracts was determined by a simple and low cost assay using brine shrimp lethality. The leaf extract of the plant exhibited moderate cytotoxic effect (LC(50): 20 µg/ml, LC(90): 40 µg/ml) whereas the bark extract exhibited low cytotoxic effect (LC(50): 50 µg/ml). In the analgesic test, the leaf extract showed comparatively high analgesic action than bark extract. There was no activity found in the leaf extract against the test bacterial strains, however bark extract exhibited a very little inhibitory effect on Staphylococcus aureus and Staphylococcus epidermidis. In the neuropharmacological test, the leaf and bark extract produced a decrease in both the time of onset of sleeping and the total sleeping time. The present study showed evidence that both leaf and bark extract of H. tiliaceus contain medicinally important bioactive compounds, thereby used as traditional medicine. Springer International Publishing 2016-07-29 /pmc/articles/PMC4967069/ /pubmed/27516947 http://dx.doi.org/10.1186/s40064-016-2891-0 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Abdul-Awal, S. M.
Nazmir, Sonia
Nasrin, Sonia
Nurunnabi, Tauhidur Rahman
Uddin, Shaikh Jamal
Evaluation of pharmacological activity of Hibiscus tiliaceus
title Evaluation of pharmacological activity of Hibiscus tiliaceus
title_full Evaluation of pharmacological activity of Hibiscus tiliaceus
title_fullStr Evaluation of pharmacological activity of Hibiscus tiliaceus
title_full_unstemmed Evaluation of pharmacological activity of Hibiscus tiliaceus
title_short Evaluation of pharmacological activity of Hibiscus tiliaceus
title_sort evaluation of pharmacological activity of hibiscus tiliaceus
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967069/
https://www.ncbi.nlm.nih.gov/pubmed/27516947
http://dx.doi.org/10.1186/s40064-016-2891-0
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