Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity

Ubiquitin is post-translationally modified by phosphorylation at several sites, but the consequences of these modifications are largely unknown. Here, we synthesize multi-milligram quantities of ubiquitin phosphorylated at serine 20, serine 57, and serine 65 via genetic code expansion. We use these...

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Detalles Bibliográficos
Autores principales: Huguenin-Dezot, Nicolas, De Cesare, Virginia, Peltier, Julien, Knebel, Axel, Kristaryianto, Yosua Adi, Rogerson, Daniel T., Kulathu, Yogesh, Trost, Matthias, Chin, Jason W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967478/
https://www.ncbi.nlm.nih.gov/pubmed/27425610
http://dx.doi.org/10.1016/j.celrep.2016.06.064

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