UDP-glucuronosyltransferase 1A1*6 and *28 polymorphisms as indicators of initial dose level of irinotecan to reduce risk of neutropenia in patients receiving FOLFIRI for colorectal cancer

BACKGROUND: Irinotecan (CPT-11)-induced neutropenia is associated with UDP-glucuronosyltransferase (UGT) 1A1*6 and *28 polymorphisms. This prospective study investigated whether using these polymorphisms to adjust the initial dose of CPT-11 as part of FOLFIRI treatment in colorectal cancer patients...

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Detalles Bibliográficos
Autores principales: Miyata, Yoshinori, Touyama, Tetsuo, Kusumi, Takaya, Morita, Yoshitaka, Mizunuma, Nobuyuki, Taniguchi, Fumihiro, Manabe, Mitsuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967590/
https://www.ncbi.nlm.nih.gov/pubmed/26710796
http://dx.doi.org/10.1007/s10147-015-0937-x

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