Cargando…

Ulcerative Colitis Activity Presenting as Fever of Unknown Origin, in a Patient with Longstanding Disease under Continuous Treatment with Mesalazine

Background. The presence of ulcerative colitis (UC) with no bowel symptoms, as fever of unknown origin (FUO), is uncommon. Objective. To describe the case of an 80-year-old woman who presented with fever, with a history of UC under treatment with mesalazine. Case Presentation. She was admitted due t...

Descripción completa

Detalles Bibliográficos
Autores principales: Voukelatou, Panagiota, Sfendouraki, Elissavet, Karianos, Theodoros, Saranti, Sofia, Tsitsimelis, Dimitrios, Vrettos, Ioannis, Kalliakmanis, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967693/
https://www.ncbi.nlm.nih.gov/pubmed/27504121
http://dx.doi.org/10.1155/2016/4396256
_version_ 1782445556679835648
author Voukelatou, Panagiota
Sfendouraki, Elissavet
Karianos, Theodoros
Saranti, Sofia
Tsitsimelis, Dimitrios
Vrettos, Ioannis
Kalliakmanis, Andreas
author_facet Voukelatou, Panagiota
Sfendouraki, Elissavet
Karianos, Theodoros
Saranti, Sofia
Tsitsimelis, Dimitrios
Vrettos, Ioannis
Kalliakmanis, Andreas
author_sort Voukelatou, Panagiota
collection PubMed
description Background. The presence of ulcerative colitis (UC) with no bowel symptoms, as fever of unknown origin (FUO), is uncommon. Objective. To describe the case of an 80-year-old woman who presented with fever, with a history of UC under treatment with mesalazine. Case Presentation. She was admitted due to fever lasting for 12 days with no associated symptoms. Seven years earlier, she was diagnosed with UC. After an extended workup for FUO that failed to reach the diagnosis, she underwent a gallium-67 scintigraphy. This revealed a persistent diffuse concentration of gallium-67 in the ascending colon at 24-hour imaging that remained stable at 48- and 72-hour imaging without any topographic change after the use of laxatives. Considering the results and in the absence of another diagnosis, the patient was treated with 30 mg prednisone daily and mesalazine, as treatment of active UC. Subsequently, the patient's condition improved markedly and the fever retreated. One month later, she was reevaluated with a gallium-67 scintigraphy with total absence of gallium-67 concentration in the ascending colon. Conclusion. UC activity must be included in the differential diagnosis of FUO in patients with longstanding disease, since fever may present alone, with no other manifestations.
format Online
Article
Text
id pubmed-4967693
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-49676932016-08-08 Ulcerative Colitis Activity Presenting as Fever of Unknown Origin, in a Patient with Longstanding Disease under Continuous Treatment with Mesalazine Voukelatou, Panagiota Sfendouraki, Elissavet Karianos, Theodoros Saranti, Sofia Tsitsimelis, Dimitrios Vrettos, Ioannis Kalliakmanis, Andreas Case Rep Med Case Report Background. The presence of ulcerative colitis (UC) with no bowel symptoms, as fever of unknown origin (FUO), is uncommon. Objective. To describe the case of an 80-year-old woman who presented with fever, with a history of UC under treatment with mesalazine. Case Presentation. She was admitted due to fever lasting for 12 days with no associated symptoms. Seven years earlier, she was diagnosed with UC. After an extended workup for FUO that failed to reach the diagnosis, she underwent a gallium-67 scintigraphy. This revealed a persistent diffuse concentration of gallium-67 in the ascending colon at 24-hour imaging that remained stable at 48- and 72-hour imaging without any topographic change after the use of laxatives. Considering the results and in the absence of another diagnosis, the patient was treated with 30 mg prednisone daily and mesalazine, as treatment of active UC. Subsequently, the patient's condition improved markedly and the fever retreated. One month later, she was reevaluated with a gallium-67 scintigraphy with total absence of gallium-67 concentration in the ascending colon. Conclusion. UC activity must be included in the differential diagnosis of FUO in patients with longstanding disease, since fever may present alone, with no other manifestations. Hindawi Publishing Corporation 2016 2016-07-18 /pmc/articles/PMC4967693/ /pubmed/27504121 http://dx.doi.org/10.1155/2016/4396256 Text en Copyright © 2016 Panagiota Voukelatou et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Voukelatou, Panagiota
Sfendouraki, Elissavet
Karianos, Theodoros
Saranti, Sofia
Tsitsimelis, Dimitrios
Vrettos, Ioannis
Kalliakmanis, Andreas
Ulcerative Colitis Activity Presenting as Fever of Unknown Origin, in a Patient with Longstanding Disease under Continuous Treatment with Mesalazine
title Ulcerative Colitis Activity Presenting as Fever of Unknown Origin, in a Patient with Longstanding Disease under Continuous Treatment with Mesalazine
title_full Ulcerative Colitis Activity Presenting as Fever of Unknown Origin, in a Patient with Longstanding Disease under Continuous Treatment with Mesalazine
title_fullStr Ulcerative Colitis Activity Presenting as Fever of Unknown Origin, in a Patient with Longstanding Disease under Continuous Treatment with Mesalazine
title_full_unstemmed Ulcerative Colitis Activity Presenting as Fever of Unknown Origin, in a Patient with Longstanding Disease under Continuous Treatment with Mesalazine
title_short Ulcerative Colitis Activity Presenting as Fever of Unknown Origin, in a Patient with Longstanding Disease under Continuous Treatment with Mesalazine
title_sort ulcerative colitis activity presenting as fever of unknown origin, in a patient with longstanding disease under continuous treatment with mesalazine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967693/
https://www.ncbi.nlm.nih.gov/pubmed/27504121
http://dx.doi.org/10.1155/2016/4396256
work_keys_str_mv AT voukelatoupanagiota ulcerativecolitisactivitypresentingasfeverofunknownorigininapatientwithlongstandingdiseaseundercontinuoustreatmentwithmesalazine
AT sfendourakielissavet ulcerativecolitisactivitypresentingasfeverofunknownorigininapatientwithlongstandingdiseaseundercontinuoustreatmentwithmesalazine
AT karianostheodoros ulcerativecolitisactivitypresentingasfeverofunknownorigininapatientwithlongstandingdiseaseundercontinuoustreatmentwithmesalazine
AT sarantisofia ulcerativecolitisactivitypresentingasfeverofunknownorigininapatientwithlongstandingdiseaseundercontinuoustreatmentwithmesalazine
AT tsitsimelisdimitrios ulcerativecolitisactivitypresentingasfeverofunknownorigininapatientwithlongstandingdiseaseundercontinuoustreatmentwithmesalazine
AT vrettosioannis ulcerativecolitisactivitypresentingasfeverofunknownorigininapatientwithlongstandingdiseaseundercontinuoustreatmentwithmesalazine
AT kalliakmanisandreas ulcerativecolitisactivitypresentingasfeverofunknownorigininapatientwithlongstandingdiseaseundercontinuoustreatmentwithmesalazine