IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo

To kill target cells, natural killer (NK) cells organize signaling from activating and inhibitory receptors to form a lytic synapse. Wiskott-Aldrich syndrome (WAS) patients have loss-of-function mutations in the actin regulator WASp and suffer from immunodeficiency with increased risk to develop lym...

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Detalles Bibliográficos
Autores principales: Kritikou, Joanna S., Dahlberg, Carin I. M., Baptista, Marisa A. P., Wagner, Arnika K., Banerjee, Pinaki P., Gwalani, Lavesh Amar, Poli, Cecilia, Panda, Sudeepta K., Kärre, Klas, Kaech, Susan M., Wermeling, Fredrik, Andersson, John, Orange, Jordan S., Brauner, Hanna, Westerberg, Lisa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967920/
https://www.ncbi.nlm.nih.gov/pubmed/27477778
http://dx.doi.org/10.1038/srep30636

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