NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence

Bacterial pneumonia is a major cause of acute lung injury and acute respiratory distress syndrome, characterized by alveolar barrier disruption. NLRP3 is best known for its ability to form inflammasomes and to regulate IL-1β and IL-18 production in myeloid cells. Here we show that NLRP3 protects the...

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Detalles Bibliográficos
Autores principales: Kostadinova, Elena, Chaput, Catherine, Gutbier, Birgitt, Lippmann, Juliane, Sander, Leif E., Mitchell, Timothy J., Suttorp, Norbert, Witzenrath, Martin, Opitz, Bastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967923/
https://www.ncbi.nlm.nih.gov/pubmed/27476670
http://dx.doi.org/10.1038/srep30943

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