Y‐632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivo

Heat shock protein 90 (Hsp90) stabilizes a variety of proteins required for cancer cell survival and has been identified as a promising drug target for cancer treatment. To date, several Hsp90 inhibitors have entered into clinical trials, but none has been approved for cancer therapy yet. Thus, expl...

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Detalles Bibliográficos
Autores principales: Wang, Wenqian, Liu, Yang, Zhao, Zhixin, Xie, Chengying, Xu, Yongping, Hu, Youhong, Quan, Haitian, Lou, Liguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968598/
https://www.ncbi.nlm.nih.gov/pubmed/27002306
http://dx.doi.org/10.1111/cas.12934

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