Cargando…

Mutational analysis of primary and metastatic colorectal cancer samples underlying the resistance to cetuximab-based therapy

PURPOSE: Although several molecular markers predicting resistance to cetuximab- or panitumumab-based therapy of metastatic colorectal cancer were described, mutations in RAS proto-oncogenes remain the only predictors being used in daily clinical practice. However, 35%–45% of wild-type RAS patients s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nemecek, Radim, Berkovcova, Jitka, Radova, Lenka, Kazda, Tomas, Mlcochova, Jitka, Vychytilova-Faltejskova, Petra, Slaby, Ondrej, Svoboda, Marek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968864/ https://www.ncbi.nlm.nih.gov/pubmed/27555788 http://dx.doi.org/10.2147/OTT.S102891

Ejemplares similares

MicroRNA expression profiling identifies miR-31-5p/3p as associated with time to progression in wild-type RAS metastatic colorectal cancer treated with cetuximab
por: Mlcochova, Jitka, et al.
Publicado: (2015)

Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer
por: Thorenoor, Nithyananda, et al.
Publicado: (2015)

Prediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients
por: Lupini, Laura, et al.
Publicado: (2015)

Identification and functional screening of microRNAs highly deregulated in colorectal cancer
por: Faltejskova, Petra, et al.
Publicado: (2012)

MicroRNA Biogenesis Pathway Genes Are Deregulated in Colorectal Cancer
por: Vychytilova-Faltejskova, Petra, et al.
Publicado: (2019)

MiR-215-5p is a tumor suppressor in colorectal cancer targeting EGFR ligand epiregulin and its transcriptional inducer HOXB9
por: Vychytilova-Faltejskova, Petra, et al.
Publicado: (2017)

MiR-215-5p Reduces Liver Metastasis in an Experimental Model of Colorectal Cancer through Regulation of ECM-Receptor Interactions and Focal Adhesion
por: Machackova, Tana, et al.
Publicado: (2020)

A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein
por: Valianatos, Georgios, et al.
Publicado: (2017)

Novel classes of non-coding RNAs and cancer
por: Sana, Jiri, et al.
Publicado: (2012)

Decreased expression levels of PIWIL1, PIWIL2, and PIWIL4 are associated with worse survival in renal cell carcinoma patients
por: Iliev, Robert, et al.
Publicado: (2016)

miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib
por: Merhautova, Jana, et al.
Publicado: (2015)

Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab
por: GRELL, PETER, et al.
Publicado: (2012)

MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma
por: Vychytilova-Faltejskova, Petra, et al.
Publicado: (2015)

MicroRNA isolation and quantification in cerebrospinal fluid: A comparative methodical study
por: Kopkova, Alena, et al.
Publicado: (2018)

Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population
por: Hezova, Renata, et al.
Publicado: (2012)

Cerebrospinal Fluid MicroRNA Signatures as Diagnostic Biomarkers in Brain Tumors
por: Kopkova, Alena, et al.
Publicado: (2019)

The Impact of Diabetes Mellitus on the Second Primary Malignancies in Colorectal Cancer Patients
por: Halamkova, Jana, et al.
Publicado: (2021)

Genome‐wide identification of urinary cell‐free microRNAs for non‐invasive detection of bladder cancer
por: Juracek, Jaroslav, et al.
Publicado: (2018)

Second primary malignancies in colorectal cancer patients
por: Halamkova, Jana, et al.
Publicado: (2021)

Small RNA Sequencing Identifies PIWI-Interacting RNAs Deregulated in Glioblastoma—piR-9491 and piR-12488 Reduce Tumor Cell Colonies In Vitro
por: Bartos, Michael, et al.
Publicado: (2021)

Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma
por: Redova, Martina, et al.
Publicado: (2012)

MicroRNA expression profile associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients
por: Svoboda, Marek, et al.
Publicado: (2012)

Epigenetic Regulation of MicroRNA Clusters and Families during Tumor Development
por: Gregorova, Jana, et al.
Publicado: (2021)

MicroRNAs as outcome predictors in patients with metastatic colorectal cancer treated with bevacizumab in combination with FOLFOX
por: Kiss, I., et al.
Publicado: (2017)

LncRNAs LY86-AS1 and VIM-AS1 Distinguish Plasma Cell Leukemia Patients from Multiple Myeloma Patients
por: Bútová, Romana, et al.
Publicado: (2021)

Epithelial-mesenchymal transition-associated microRNA/mRNA signature is linked to metastasis and prognosis in clear-cell renal cell carcinoma
por: Mlcochova, Hana, et al.
Publicado: (2016)

The Significance of MicroRNAs in the Molecular Pathology of Brain Metastases
por: Siegl, Frantisek, et al.
Publicado: (2022)

Involvement of Small Non-Coding RNA and Cell Antigens in Pathogenesis of Extramedullary Multiple Myeloma
por: Vlachová, Monika, et al.
Publicado: (2022)

MicroRNAs in colorectal cancer: translation of molecular biology into clinical application
por: Slaby, Ondrej, et al.
Publicado: (2009)

Identification of microRNA signatures in umbilical cord blood associated with maternal characteristics
por: Juracek, Jaroslav, et al.
Publicado: (2019)

Long Non-Coding RNAs in Multiple Myeloma
por: Butova, Romana, et al.
Publicado: (2019)

Radiotherapy of Glioblastoma 15 Years after the Landmark Stupp’s Trial: More Controversies than Standards?
por: Kazda, Tomas, et al.
Publicado: (2018)

Epithelial to mesenchymal transition and microRNA expression are associated with spindle and apocrine cell morphology in triple-negative breast cancer
por: Koleckova, Marketa, et al.
Publicado: (2021)

Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma
por: Fedorko, Michal, et al.
Publicado: (2017)

Individualization of Treatment Improves the Survival of Children With High-Risk Solid Tumors: Comparative Patient Series Analysis in a Real-Life Scenario
por: Kyr, Michal, et al.
Publicado: (2019)

BSCI-01. Small RNAseq analysis of microRNAs in brain metastasis
por: Jancalek, Radim, et al.
Publicado: (2021)

Cetuximab treatment in a patient with metastatic colorectal cancer and psoriasis
por: Neyns, B., et al.
Publicado: (2008)

Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival
por: Sana, Jiri, et al.
Publicado: (2018)

Contrast-Enhanced Ultrasonography for Differential Diagnosis of Benign and Malignant Thyroid Lesions: Single-Institutional Prospective Study of Qualitative and Quantitative CEUS Characteristics
por: Petrasova, Hana, et al.
Publicado: (2022)

Mutations of KRAS/NRAS/BRAF predict cetuximab resistance in metastatic colorectal cancer patients
por: Hsu, Hung-Chih, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_7ksl4v9ejv7bitbe9gu7714n64