Flurbiprofen–antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling

Flurbiprofen–antioxidant mutual prodrugs were synthesized to reduce the gastrointestinal (GI) effects associated with flurbiprofen. For reducing the GI toxicity, the free carboxylic group (–COOH) was temporarily masked by esterification with phenolic –OH of natural antioxidants vanillin, thymol, umb...

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Detalles Bibliográficos
Autores principales: Ashraf, Zaman, Alamgeer, Kanwal, Munazza, Hassan, Mubashir, Abdullah, Sahar, Waheed, Mamuna, Ahsan, Haseeb, Kim, Song Ja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968865/
https://www.ncbi.nlm.nih.gov/pubmed/27555750
http://dx.doi.org/10.2147/DDDT.S109318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968865/
https://www.ncbi.nlm.nih.gov/pubmed/27555750
http://dx.doi.org/10.2147/DDDT.S109318

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