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Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy

Gold nanoclusters (Au NCs) have exhibited great advantages in medical diagnostics and therapies due to their efficient renal clearance and high tumor uptake. The in vivo effects of the surface chemistry of Au NCs are important for the development of both nanobiological interfaces and potential clini...

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Autores principales: Wang, Jun-Ying, Chen, Jie, Yang, Jiang, Wang, Hao, Shen, Xiu, Sun, Yuan-Ming, Guo, Meili, Zhang, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968867/
https://www.ncbi.nlm.nih.gov/pubmed/27555769
http://dx.doi.org/10.2147/IJN.S106073
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author Wang, Jun-Ying
Chen, Jie
Yang, Jiang
Wang, Hao
Shen, Xiu
Sun, Yuan-Ming
Guo, Meili
Zhang, Xiao-Dong
author_facet Wang, Jun-Ying
Chen, Jie
Yang, Jiang
Wang, Hao
Shen, Xiu
Sun, Yuan-Ming
Guo, Meili
Zhang, Xiao-Dong
author_sort Wang, Jun-Ying
collection PubMed
description Gold nanoclusters (Au NCs) have exhibited great advantages in medical diagnostics and therapies due to their efficient renal clearance and high tumor uptake. The in vivo effects of the surface chemistry of Au NCs are important for the development of both nanobiological interfaces and potential clinical contrast reagents, but these properties are yet to be fully investigated. In this study, we prepared glutathione-protected Au NCs of a similar hydrodynamic size but with three different surface charges: positive, negative, and neutral. Their in vivo biodistribution, excretion, and toxicity were investigated over a 90-day period, and tumor uptake and potential application to radiation therapy were also evaluated. The results showed that the surface charge greatly influenced pharmacokinetics, particularly renal excretion and accumulation in kidney, liver, spleen, and testis. Negatively charged Au NCs displayed lower excretion and increased tumor uptake, indicating a potential for NC-based therapeutics, whereas positively charged clusters caused transient side effects on the peripheral blood system.
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spelling pubmed-49688672016-08-23 Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy Wang, Jun-Ying Chen, Jie Yang, Jiang Wang, Hao Shen, Xiu Sun, Yuan-Ming Guo, Meili Zhang, Xiao-Dong Int J Nanomedicine Original Research Gold nanoclusters (Au NCs) have exhibited great advantages in medical diagnostics and therapies due to their efficient renal clearance and high tumor uptake. The in vivo effects of the surface chemistry of Au NCs are important for the development of both nanobiological interfaces and potential clinical contrast reagents, but these properties are yet to be fully investigated. In this study, we prepared glutathione-protected Au NCs of a similar hydrodynamic size but with three different surface charges: positive, negative, and neutral. Their in vivo biodistribution, excretion, and toxicity were investigated over a 90-day period, and tumor uptake and potential application to radiation therapy were also evaluated. The results showed that the surface charge greatly influenced pharmacokinetics, particularly renal excretion and accumulation in kidney, liver, spleen, and testis. Negatively charged Au NCs displayed lower excretion and increased tumor uptake, indicating a potential for NC-based therapeutics, whereas positively charged clusters caused transient side effects on the peripheral blood system. Dove Medical Press 2016-07-27 /pmc/articles/PMC4968867/ /pubmed/27555769 http://dx.doi.org/10.2147/IJN.S106073 Text en © 2016 Wang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Wang, Jun-Ying
Chen, Jie
Yang, Jiang
Wang, Hao
Shen, Xiu
Sun, Yuan-Ming
Guo, Meili
Zhang, Xiao-Dong
Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
title Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
title_full Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
title_fullStr Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
title_full_unstemmed Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
title_short Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
title_sort effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968867/
https://www.ncbi.nlm.nih.gov/pubmed/27555769
http://dx.doi.org/10.2147/IJN.S106073
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