MAD2γ, a novel MAD2 isoform, reduces mitotic arrest and is associated with resistance in testicular germ cell tumors

Background: Prolonged mitotic arrest in response to anti-cancer chemotherapeutics, such as DNA-damaging agents, induces apoptosis, mitotic catastrophe, and senescence. Disruptions in mitotic checkpoints contribute resistance to DNA-damaging agents in cancer. MAD2 has been associated with checkpoint...

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Detalles Bibliográficos
Autores principales: López-Saavedra, Alejandro, Ramírez-Otero, Miguel, Díaz-Chávez, José, Cáceres-Gutiérrez, Rodrigo, Justo-Garrido, Monserrat, Andonegui, Marco A., Mendoza, Julia, Downie-Ruíz, Ángela, Cortés-González, Carlo, Reynoso, Nancy, Castro-Hernández, Clementina, Domínguez-Gómez, Guadalupe, Santibáñez, Miguel, Fabián-Morales, Eunice, Pruefer, Franz, Luna-Maldonado, Fernando, González-Barrios, Rodrigo, Herrera, Luis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968973/
https://www.ncbi.nlm.nih.gov/pubmed/27315568
http://dx.doi.org/10.1080/15384101.2016.1198863

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