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Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides

PrimPol is a DNA damage tolerance enzyme possessing both translesion synthesis (TLS) and primase activities. To uncover its potential role in TLS-mediated IgV(λ) hypermutation and define its interplay with other TLS polymerases, PrimPol(−/−) and PrimPol(−/−)/Polη(−/−)/Polζ (−/−) gene knockouts were...

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Detalles Bibliográficos
Autores principales:	Kobayashi, Kaori, Guilliam, Thomas A., Tsuda, Masataka, Yamamoto, Junpei, Bailey, Laura J., Iwai, Shigenori, Takeda, Shunichi, Doherty, Aidan J., Hirota, Kouji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968974/ https://www.ncbi.nlm.nih.gov/pubmed/27230014 http://dx.doi.org/10.1080/15384101.2016.1191711

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