Antimyeloma activity of bromodomain inhibitors on the human myeloma cell line U266 by downregulation of MYCL

Bromodomain and extraterminal protein (BET) inhibitors suppress the expression of c-MYC. U266, a human myeloma cell line, expresses the MYCL gene, but not the c-MYC gene. Our aim was to analyse the antimyeloma activity of BET inhibitors on U266 cells. Two BET inhibitors, I-BET151 and JQ1, were teste...

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Detalles Bibliográficos
Autores principales: Suzuki, Kazuhito, Yamamoto, Kouhei, Arakawa, Yasuhiro, Yamada, Hisashi, Aiba, Keisuke, Kitagawa, Masanobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Preclinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969056/
https://www.ncbi.nlm.nih.gov/pubmed/27276402
http://dx.doi.org/10.1097/CAD.0000000000000389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969056/
https://www.ncbi.nlm.nih.gov/pubmed/27276402
http://dx.doi.org/10.1097/CAD.0000000000000389

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