Vitamin A-retinoid signaling in pulmonary development and disease

Retinoic acid (RA), the active form of vitamin A, regulates key developmental processes in multiple organs. In the developing lung, RA is crucial for normal growth and differentiation of airways. Disruption in RA signaling or vitamin A deficiency (VAD) has been linked to aberrant development of the...

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Detalles Bibliográficos
Autores principales: Marquez, Hector A., Cardoso, Wellington V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969253/
https://www.ncbi.nlm.nih.gov/pubmed/27480876
http://dx.doi.org/10.1186/s40348-016-0054-6
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author Marquez, Hector A.
Cardoso, Wellington V.
author_facet Marquez, Hector A.
Cardoso, Wellington V.
author_sort Marquez, Hector A.
collection PubMed
description Retinoic acid (RA), the active form of vitamin A, regulates key developmental processes in multiple organs. In the developing lung, RA is crucial for normal growth and differentiation of airways. Disruption in RA signaling or vitamin A deficiency (VAD) has been linked to aberrant development of the lung including alterations in the airway smooth muscle (SM) differentiation, development, and function. These alterations have been linked to disease states including asthma in both human and animal models.
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spelling pubmed-49692532016-08-10 Vitamin A-retinoid signaling in pulmonary development and disease Marquez, Hector A. Cardoso, Wellington V. Mol Cell Pediatr Mini Review Retinoic acid (RA), the active form of vitamin A, regulates key developmental processes in multiple organs. In the developing lung, RA is crucial for normal growth and differentiation of airways. Disruption in RA signaling or vitamin A deficiency (VAD) has been linked to aberrant development of the lung including alterations in the airway smooth muscle (SM) differentiation, development, and function. These alterations have been linked to disease states including asthma in both human and animal models. Springer Berlin Heidelberg 2016-08-01 /pmc/articles/PMC4969253/ /pubmed/27480876 http://dx.doi.org/10.1186/s40348-016-0054-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Mini Review
Marquez, Hector A.
Cardoso, Wellington V.
Vitamin A-retinoid signaling in pulmonary development and disease
title Vitamin A-retinoid signaling in pulmonary development and disease
title_full Vitamin A-retinoid signaling in pulmonary development and disease
title_fullStr Vitamin A-retinoid signaling in pulmonary development and disease
title_full_unstemmed Vitamin A-retinoid signaling in pulmonary development and disease
title_short Vitamin A-retinoid signaling in pulmonary development and disease
title_sort vitamin a-retinoid signaling in pulmonary development and disease
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969253/
https://www.ncbi.nlm.nih.gov/pubmed/27480876
http://dx.doi.org/10.1186/s40348-016-0054-6
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