Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus

The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs)...

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Detalles Bibliográficos
Autores principales: Bento-de-Souza, Luciana, Victor, Jefferson R., Bento-de-Souza, Luiz C., Arrais-Santos, Magaly, Rangel-Santos, Andréia C., Pereira-Costa, Érica, Raniero-Fernandes, Elaine, Seixas-Duarte, Maria I., Oliveira-Filho, João B., Silva Duarte, Alberto J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969261/
https://www.ncbi.nlm.nih.gov/pubmed/27504259
http://dx.doi.org/10.1016/j.rinim.2016.04.001
Descripción
Sumario:The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus.

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